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    Lrriq4 leucine-rich repeats and IQ motif containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 68307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrriq4provided by MGI
    Official Full Name
    leucine-rich repeats and IQ motif containing 4provided by MGI
    Primary source
    MGI:MGI:1915557
    See related
    Ensembl:ENSMUSG00000027703 AllianceGenome:MGI:1915557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930558O21Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Orthologous to human LRRIQ4 (leucine rich repeats and IQ motif containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 12.1) See more
    Orthologs
    human all
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    Genomic context

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    See Lrriq4 in Genome Data Viewer
    Location:
    3 A3; 3 14.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30698636..30726583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30644487..30672434)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2661 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:30500978-30501161 Neighboring gene nuclear encoded tRNA valine 8 (anticodon AAC) Neighboring gene myoneurin Neighboring gene leucine rich repeat containing 34 Neighboring gene STARR-seq mESC enhancer starr_07297 Neighboring gene STARR-seq mESC enhancer starr_07298 Neighboring gene STARR-seq mESC enhancer starr_07299 Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462 Neighboring gene STARR-seq mESC enhancer starr_07301 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene predicted gene, 33590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and IQ domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290510.2 → NP_001277439.1  leucine-rich repeat and IQ domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001277439.1

      Status: VALIDATED

      Source sequence(s)
      AC120377
      Consensus CDS
      CCDS71229.1
      UniProtKB/TrEMBL
      Q9D2F4
      Related
      ENSMUSP00000103900.3, ENSMUST00000108265.3
      Conserved Domains (4) summary
      cd00116
      Location:221 → 382
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:257 → 279
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:420 → 459
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:420 → 477
      LRR_8; Leucine rich repeat

    2. NM_026668.3 → NP_080944.2  leucine-rich repeat and IQ domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_080944.2

      Status: VALIDATED

      Source sequence(s)
      AC120377
      Consensus CDS
      CCDS38406.1
      UniProtKB/Swiss-Prot
      A6H6A4, Q9D5Q5
      UniProtKB/TrEMBL
      Q9D2F4
      Related
      ENSMUSP00000103902.2, ENSMUST00000108267.8
      Conserved Domains (4) summary
      cd00116
      Location:236 → 397
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:272 → 294
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:435 → 474
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:435 → 492
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      30698636..30726583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249709.3 → XP_011248011.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      Q9D2F4
      Conserved Domains (4) summary
      smart00015
      Location:543 → 563
      IQ; Calmodulin-binding motif
      COG4886
      Location:228 → 521
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:275 → 297
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:48 → 309
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_011249710.3 → XP_011248012.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X2

      Conserved Domains (2) summary
      COG4886
      Location:169 → 414
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:206 → 228
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H6A4.1 GenPept UniProtKB/Swiss-Prot:A6H6A4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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