Il1rapl2 interleukin 1 receptor accessory protein-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il1rapl2provided by MGI
Official Full Name: interleukin 1 receptor accessory protein-like 2provided by MGI
Primary source: MGI:MGI:1913106
See related: Ensembl:ENSMUSG00000059203 AllianceGenome:MGI:1913106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable NAD+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1, type II, blocking receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of presynapse assembly. Predicted to be located in membrane. Predicted to be active in cell surface; glutamatergic synapse; and plasma membrane. Is expressed in brain and spinal cord floor plate. Orthologous to human IL1RAPL2 (interleukin 1 receptor accessory protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X F1; X 59.1 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (136471503..137749826)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (137570754..138849077)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

DXMit37 (e-PCR), detects polymorphism
- UniSTS:132144

px-64g1 (e-PCR)
- UniSTS:258099

DXMit66 (e-PCR), detects polymorphism
- UniSTS:132172

px-39d3 (e-PCR)
- UniSTS:258396

px-1a8 (e-PCR)
- UniSTS:257377

15.MMHAP11FLE3.seq (e-PCR)
- UniSTS:123247

px-21d1 (e-PCR)
- UniSTS:257395

px-36b8 (e-PCR)
- UniSTS:257652

px-37c8 (e-PCR)
- UniSTS:257675

STS-Z41083 (e-PCR)
- UniSTS:16802

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables interleukin-1, type II, blocking receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: X-linked interleukin-1 receptor accessory protein-like 2

Names: IL-1 receptor accessory protein-like 2; IL-1-RAPL-2; IL-1RAPL-2; IL1RAPL-2; IL1RAPL-2-related protein; TIGIRR-1; three immunoglobulin domain-containing IL-1 receptor-related 1

NP_109613.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030688.2 → NP_109613.1 X-linked interleukin-1 receptor accessory protein-like 2 precursor

See identical proteins and their annotated locations for NP_109613.1

Status: VALIDATED

Source sequence(s)

AK045976, AL672067

Consensus CDS

CCDS30429.1

UniProtKB/Swiss-Prot

Q9ER66, Q9ERS6

UniProtKB/TrEMBL

Q0VBP3

Related

ENSMUSP00000108686.2, ENSMUST00000113063.8

Conserved Domains (4) summary

cd05896
Location:32 → 133

Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)

smart00255
Location:401 → 559

TIR; Toll - interleukin 1 - resistance

smart00410
Location:250 → 347

IG_like; Immunoglobulin like

cd05757
Location:146 → 237

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins