IL15RA interleukin 15 receptor subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL15RAprovided by HGNC
Official Full Name: interleukin 15 receptor subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:5978
See related: Ensembl:ENSG00000134470 MIM:601070; AllianceGenome:HGNC:5978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD215
Summary: This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
Expression: Ubiquitous expression in gall bladder (RPKM 5.8), lung (RPKM 5.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p15.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (5948900..5978741, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (5949580..5979435, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (5994334..6020704, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15alpha receptor complex.
Title: Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15α receptor complex.
miRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics.
Title: miRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics.
Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction.
Title: Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction.
Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor alpha Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
Title: Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
Tumor cell-expressed IL-15Ralpha drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer.
Title: Tumor cell-expressed IL-15Rα drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer.
RUNX2 and IL-15RA Polymorphisms associated with OPLL in the Han and Mongolian population.
Title: RUNX2 and IL-15RA Polymorphisms associated with OPLL in the Han and Mongolian population.
The expression levels of CHI3L1 and IL15Ralpha correlate with TGM2 in duodenum biopsies of patients with celiac disease.
Title: The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease.
IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity.
Title: IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity.
IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation.
Title: Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα.
Data show that the response of NK cells activated by ULBP2 was augmented by an interaction between NKG2D ligand 2 protein (ULBP2)-bound natural killer group 2D (NKG2D) and IL- interleukin 15 receptor (IL-15R).
Title: A nanoscale reorganization of the IL-15 receptor is triggered by NKG2D in a ligand-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of bronchodilator response in asthmatics. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IL15RA	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of interleukin 15 receptor, alpha (IL15RA) in human B cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-U31628 (e-PCR)
- UniSTS:82476

RH69914 (e-PCR)
- UniSTS:78677

IL15RA_751 (e-PCR)
- UniSTS:277364

NoName (e-PCR)
- UniSTS:494741

NoName (e-PCR)
- UniSTS:481974

STS-AA028956 (e-PCR)
- UniSTS:23248

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine receptor activity	TAS Traceable Author Statement more info	PubMed
enables interleukin-15 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-15 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-15-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-15 receptor subunit alpha

Names: interleukin 15 receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243539.2 → NP_001230468.1 interleukin-15 receptor subunit alpha isoform 3

See identical proteins and their annotated locations for NP_001230468.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses a downstream, in-frame start codon, compared to variant 4. The encoded isoform (3) has a shorter N-terminus compared to isoform 4.

Source sequence(s)

AA847313, AF035279, AL137186, BC107777

Consensus CDS

CCDS58069.1

UniProtKB/Swiss-Prot

Q13261

Related

ENSP00000431529.2, ENST00000525219.6
NM_001256765.1 → NP_001243694.1 interleukin-15 receptor subunit alpha isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).

Source sequence(s)

AA847313, AF035279, DC298692, HQ401283

Consensus CDS

CCDS73065.1

UniProtKB/TrEMBL

A0A0A0MS77, G8CVM3

Related

ENSP00000380421.3, ENST00000397248.6

Conserved Domains (1) summary

cd00033
Location:119 → 180

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_001351095.2 → NP_001338024.1 interleukin-15 receptor subunit alpha isoform 5

Status: REVIEWED

Source sequence(s)

AA847313, AK304211, AL137186, BG675498, CA308853, U31628

Conserved Domains (1) summary

cd00033
Location:91 → 152

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_001351096.1 → NP_001338025.1 interleukin-15 receptor subunit alpha isoform 6

Status: REVIEWED

Source sequence(s)

AF035279, AL137186, BG675498, CA308853, HQ401283
NM_001351097.2 → NP_001338026.1 interleukin-15 receptor subunit alpha isoform 7

Status: REVIEWED

Source sequence(s)

AF035279, AL137186, BC107777, CA308853

UniProtKB/TrEMBL

E7ETI1

Related

ENSP00000380420.4, ENST00000397246.7
NM_002189.4 → NP_002180.1 interleukin-15 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_002180.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame 5' coding exon, compared to variant 4. This results in a shorter isoform (1), compared to isoform 4.

Source sequence(s)

AA847313, U31628

Consensus CDS

CCDS7074.1

UniProtKB/Swiss-Prot

B4E2C2, Q13261, Q3B769, Q5JVA1, Q5JVA2, Q5JVA4, Q6B0J2, Q7LDR4, Q7Z609

UniProtKB/TrEMBL

G8CVM3

Related

ENSP00000369312.3, ENST00000379977.8

Conserved Domains (1) summary

cd00033
Location:33 → 94

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_172200.3 → NP_751950.2 interleukin-15 receptor subunit alpha isoform 2 precursor

See identical proteins and their annotated locations for NP_751950.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame coding exon, compared to variant 4. This results in a shorter isoform (2), compared to isoform 4.

Source sequence(s)

AA847313, AK304211, U31628

Consensus CDS

CCDS7075.2

UniProtKB/Swiss-Prot

Q13261

Related

ENSP00000435454.1, ENST00000528354.5

Conserved Domains (1) summary

cd00033
Location:33 → 94

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RNA

NR_046362.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate 5' exon structure, compared to variant 4. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 4.

Source sequence(s)

AA847313, AF035279, AL137186, BC065506

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

5948900..5978741 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011519474.3 → XP_011517776.1 interleukin-15 receptor subunit alpha isoform X20
XM_011519471.3 → XP_011517773.1 interleukin-15 receptor subunit alpha isoform X15

Conserved Domains (1) summary

PRK14959
Location:78 → 188

PRK14959; DNA polymerase III subunits gamma and tau; Provisional
XM_011519464.3 → XP_011517766.1 interleukin-15 receptor subunit alpha isoform X4

Conserved Domains (1) summary

cd00033
Location:91 → 152

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_011519463.3 → XP_011517765.1 interleukin-15 receptor subunit alpha isoform X3

Conserved Domains (1) summary

cd00033
Location:142 → 203

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_011519461.3 → XP_011517763.1 interleukin-15 receptor subunit alpha isoform X1

Conserved Domains (2) summary

cd00033
Location:142 → 203

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam05466
Location:212 → 317

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_047425185.1 → XP_047281141.1 interleukin-15 receptor subunit alpha isoform X18
XM_011519475.3 → XP_011517777.1 interleukin-15 receptor subunit alpha isoform X21
XM_011519472.3 → XP_011517774.1 interleukin-15 receptor subunit alpha isoform X17
XM_011519470.3 → XP_011517772.1 interleukin-15 receptor subunit alpha isoform X12

Conserved Domains (1) summary

cd00033
Location:68 → 129

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_047425188.1 → XP_047281144.1 interleukin-15 receptor subunit alpha isoform X25
XM_011519467.3 → XP_011517769.1 interleukin-15 receptor subunit alpha isoform X7

Conserved Domains (1) summary

cd00033
Location:68 → 129

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_011519462.3 → XP_011517764.1 interleukin-15 receptor subunit alpha isoform X2

Conserved Domains (2) summary

cd00033
Location:119 → 180

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam05466
Location:189 → 294

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_017016197.3 → XP_016871686.1 interleukin-15 receptor subunit alpha isoform X18
XM_011519468.2 → XP_011517770.1 interleukin-15 receptor subunit alpha isoform X8

Conserved Domains (2) summary

cd00033
Location:142 → 203

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam05466
Location:212 → 317

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_047425191.1 → XP_047281147.1 interleukin-15 receptor subunit alpha isoform X28
XM_017016198.2 → XP_016871687.1 interleukin-15 receptor subunit alpha isoform X22
XM_017016195.2 → XP_016871684.1 interleukin-15 receptor subunit alpha isoform X13
XM_047425184.1 → XP_047281140.1 interleukin-15 receptor subunit alpha isoform X16
XM_011519469.2 → XP_011517771.1 interleukin-15 receptor subunit alpha isoform X9

Conserved Domains (1) summary

cd00033
Location:142 → 203

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_047425182.1 → XP_047281138.1 interleukin-15 receptor subunit alpha isoform X11
XM_011519465.2 → XP_011517767.1 interleukin-15 receptor subunit alpha isoform X5

Conserved Domains (1) summary

cd00033
Location:142 → 203

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_011519466.3 → XP_011517768.1 interleukin-15 receptor subunit alpha isoform X6

Conserved Domains (2) summary

cd00033
Location:142 → 203

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam05466
Location:212 → 317

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_011519476.3 → XP_011517778.1 interleukin-15 receptor subunit alpha isoform X29

Related

ENSP00000380422.2, ENST00000397250.6
XM_011519477.3 → XP_011517779.1 interleukin-15 receptor subunit alpha isoform X30

Related

ENSP00000369306.1, ENST00000379971.5
XM_047425189.1 → XP_047281145.1 interleukin-15 receptor subunit alpha isoform X26
XM_047425190.1 → XP_047281146.1 interleukin-15 receptor subunit alpha isoform X27
XM_047425187.1 → XP_047281143.1 interleukin-15 receptor subunit alpha isoform X24

Related

ENSP00000435995.1, ENST00000530685.5
XM_047425186.1 → XP_047281142.1 interleukin-15 receptor subunit alpha isoform X19

UniProtKB/TrEMBL

K9N2S6

Related

ENSP00000380426.3, ENST00000397255.7
XM_047425183.1 → XP_047281139.1 interleukin-15 receptor subunit alpha isoform X14

UniProtKB/TrEMBL

G8CVM3
XM_047425181.1 → XP_047281137.1 interleukin-15 receptor subunit alpha isoform X10

UniProtKB/TrEMBL

K9N2S6
XM_017016199.2 → XP_016871688.1 interleukin-15 receptor subunit alpha isoform X23

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

5949580..5979435 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365790.1 → XP_054221765.1 interleukin-15 receptor subunit alpha isoform X25
XM_054365785.1 → XP_054221760.1 interleukin-15 receptor subunit alpha isoform X20
XM_054365779.1 → XP_054221754.1 interleukin-15 receptor subunit alpha isoform X15
XM_054365768.1 → XP_054221743.1 interleukin-15 receptor subunit alpha isoform X4
XM_054365767.1 → XP_054221742.1 interleukin-15 receptor subunit alpha isoform X3
XM_054365765.1 → XP_054221740.1 interleukin-15 receptor subunit alpha isoform X1
XM_054365782.1 → XP_054221757.1 interleukin-15 receptor subunit alpha isoform X18
XM_054365786.1 → XP_054221761.1 interleukin-15 receptor subunit alpha isoform X21
XM_054365781.1 → XP_054221756.1 interleukin-15 receptor subunit alpha isoform X17
XM_054365776.1 → XP_054221751.1 interleukin-15 receptor subunit alpha isoform X12
XM_054365771.1 → XP_054221746.1 interleukin-15 receptor subunit alpha isoform X7
XM_054365766.1 → XP_054221741.1 interleukin-15 receptor subunit alpha isoform X2
XM_054365783.1 → XP_054221758.1 interleukin-15 receptor subunit alpha isoform X18
XM_054365772.1 → XP_054221747.1 interleukin-15 receptor subunit alpha isoform X8
XM_054365793.1 → XP_054221768.1 interleukin-15 receptor subunit alpha isoform X28
XM_054365787.1 → XP_054221762.1 interleukin-15 receptor subunit alpha isoform X22
XM_054365777.1 → XP_054221752.1 interleukin-15 receptor subunit alpha isoform X13
XM_054365780.1 → XP_054221755.1 interleukin-15 receptor subunit alpha isoform X16
XM_054365773.1 → XP_054221748.1 interleukin-15 receptor subunit alpha isoform X9
XM_054365775.1 → XP_054221750.1 interleukin-15 receptor subunit alpha isoform X11
XM_054365769.1 → XP_054221744.1 interleukin-15 receptor subunit alpha isoform X5
XM_054365770.1 → XP_054221745.1 interleukin-15 receptor subunit alpha isoform X6
XM_054365794.1 → XP_054221769.1 interleukin-15 receptor subunit alpha isoform X29
XM_054365795.1 → XP_054221770.1 interleukin-15 receptor subunit alpha isoform X30
XM_054365791.1 → XP_054221766.1 interleukin-15 receptor subunit alpha isoform X26
XM_054365792.1 → XP_054221767.1 interleukin-15 receptor subunit alpha isoform X27
XM_054365789.1 → XP_054221764.1 interleukin-15 receptor subunit alpha isoform X24
XM_054365784.1 → XP_054221759.1 interleukin-15 receptor subunit alpha isoform X19

UniProtKB/TrEMBL

K9N2S6
XM_054365778.1 → XP_054221753.1 interleukin-15 receptor subunit alpha isoform X14

UniProtKB/TrEMBL

G8CVM3
XM_054365774.1 → XP_054221749.1 interleukin-15 receptor subunit alpha isoform X10

UniProtKB/TrEMBL

K9N2S6
XM_054365788.1 → XP_054221763.1 interleukin-15 receptor subunit alpha isoform X23