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    ULK1 unc-51 like autophagy activating kinase 1 [ Homo sapiens (human) ]

    Gene ID: 8408, updated on 10-Dec-2024

    Summary

    Official Symbol
    ULK1provided by HGNC
    Official Full Name
    unc-51 like autophagy activating kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:12558
    See related
    Ensembl:ENSG00000177169 MIM:603168; AllianceGenome:HGNC:12558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATG1; ATG1A; UNC51; hATG1; Unc51.1
    Summary
    Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including protein phosphorylation; regulation of autophagy; and regulation of protein lipidation. Located in bounding membrane of organelle; cytosol; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex and phagophore assembly site. Is active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ULK1 in Genome Data Viewer
    Location:
    12q24.33
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (131894622..131923150)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (131939343..131971098)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132379167..132407695)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132347237-132347900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132348565-132349228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132352369-132352965 Neighboring gene uncharacterized LOC124903059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5102 Neighboring gene Sharpr-MPRA regulatory region 8404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132381351-132382148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132384711-132385228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132385229-132385746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132385901-132386674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132386675-132387447 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7373 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:132409300-132410176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5106 Neighboring gene PUS1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5107 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25941 Neighboring gene pseudouridine synthase 1 Neighboring gene Sharpr-MPRA regulatory region 9670

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef downregulates the mRNA expression of ULK1 in human mesenchymal stem cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ38455, FLJ46475

    Gene Ontology Provided by GOA

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables GTPase binding PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    enables ribosomal protein S6 kinase activity  
    enables small GTPase binding PubMed 
    Items 1 - 25 of 32
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in autophagosome assembly  
    involved_in autophagosome assembly PubMed 
    involved_in autophagy PubMed 
    involved_in autophagy PubMed 
    involved_in autophagy PubMed 
    involved_in autophagy  
    involved_in axon extension  
    involved_in cellular response to nutrient levels  
    involved_in cellular response to stress PubMed 
    involved_in chromatin remodeling  
    involved_in macroautophagy PubMed 
    involved_in macroautophagy  
    involved_in mitophagy  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of collateral sprouting  
    involved_in negative regulation of protein-containing complex assembly PubMed 
    involved_in neuron projection development PubMed 
    involved_in neuron projection regeneration  
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in piecemeal microautophagy of the nucleus  
    involved_in positive regulation of autophagosome assembly  
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in protein autophosphorylation PubMed 
    involved_in protein localization PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of autophagy  
    involved_in regulation of macroautophagy PubMed 
    involved_in regulation of protein lipidation PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in response to starvation  
    involved_in response to starvation  
    involved_in reticulophagy  
    involved_in signal transduction  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex PubMed 
    is_active_in autophagosome  
    located_in autophagosome PubMed 
    located_in autophagosome membrane PubMed 
    located_in axon  
    is_active_in cytoplasm  
    is_active_in cytoplasm PubMed 
    is_active_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in endoplasmic reticulum membrane  
    located_in mitochondrial outer membrane  
    located_in omegasome membrane PubMed 
    is_active_in phagophore assembly site  
    located_in phagophore assembly site PubMed 
    is_active_in phagophore assembly site membrane  
    located_in phagophore assembly site membrane PubMed 
    located_in recycling endosome  

    General protein information

    Preferred Names
    serine/threonine-protein kinase ULK1
    Names
    ATG1 autophagy related 1 homolog
    autophagy-related protein 1 homolog
    NP_003556.2
    XP_011537100.1
    XP_011537101.1
    XP_054229379.1
    XP_054229380.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003565.4 → NP_003556.2  serine/threonine-protein kinase ULK1

      Status: VALIDATED

      Source sequence(s)
      AC131009
      Consensus CDS
      CCDS9274.1
      UniProtKB/Swiss-Prot
      O75385, Q9UQ28
      Related
      ENSP00000324560.3, ENST00000321867.6
      Conserved Domains (2) summary
      cd14202
      Location:13 → 279
      STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
      pfam12063
      Location:878 → 1044
      DUF3543; Domain of unknown function (DUF3543)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      131894622..131923150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538798.4 → XP_011537100.1  serine/threonine-protein kinase ULK1 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:16 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14202
      Location:13 → 279
      STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
      pfam12063
      Location:860 → 1067
      DUF3543; Domain of unknown function (DUF3543)
    2. XM_011538799.3 → XP_011537101.1  serine/threonine-protein kinase ULK1 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:16 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14202
      Location:13 → 279
      STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
      pfam12063
      Location:831 → 1038
      DUF3543; Domain of unknown function (DUF3543)

    RNA

    1. XR_007063134.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      131939343..131971098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373404.1 → XP_054229379.1  serine/threonine-protein kinase ULK1 isoform X1

    2. XM_054373405.1 → XP_054229380.1  serine/threonine-protein kinase ULK1 isoform X2

    RNA

    1. XR_008488691.1 RNA Sequence

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