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    SLC38A1 solute carrier family 38 member 1 [ Homo sapiens (human) ]

    Gene ID: 81539, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC38A1provided by HGNC
    Official Full Name
    solute carrier family 38 member 1provided by HGNC
    Primary source
    HGNC:HGNC:13447
    See related
    Ensembl:ENSG00000111371 MIM:608490; AllianceGenome:HGNC:13447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATA1; NAT2; SAT1; SNAT1
    Summary
    Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in lymph node (RPKM 24.7), thyroid (RPKM 21.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC38A1 in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (46183063..46269043, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (46142659..46228603, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (46576846..46662826, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SR-related CTD associated factor 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:46384079-46384792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6233 Neighboring gene ribosomal protein L13a pseudogene 21 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:46442615-46443116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:46443117-46443616 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:46464825-46466024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6235 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:46478170-46479369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:46660317-46661300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6242 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:46662284-46663266 Neighboring gene uncharacterized LOC105378248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:46674619-46675430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6245 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:46765735-46766438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4385 Neighboring gene solute carrier family 38 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta. Wang H, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891391
    2. Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex. Melone M, et al. Cereb Cortex, 2004 May. PMID 15054072
    3. Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues. Kondoh N, et al. Int J Oncol, 2007 Jul. PMID 17549407
    4. SNAT1 and a family with high rates of suicidal behavior. Ernst C, et al. Neuroscience, 2009 Aug 18. PMID 19442705
    5. The contribution of SNAT1 to system A amino acid transporter activity in human placental trophoblast. Desforges M, et al. Biochem Biophys Res Commun, 2010 Jul 16. PMID 20599747, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3-mediated m[6]A methylation of SLC38A1 stimulates cervical cancer growth.
      Title: METTL3-mediated m(6)A methylation of SLC38A1 stimulates cervical cancer growth.
    2. OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1.
      Title: OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1.
    3. CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer.
      Title: CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer.
    4. miRNA-432 and SLC38A1 as Predictors of Hepatocellular Carcinoma Complicated with Alcoholic Steatohepatitis.
      Title: miRNA-432 and SLC38A1 as Predictors of Hepatocellular Carcinoma Complicated with Alcoholic Steatohepatitis.
    5. CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR-485-5p/SLC38A1 axis.
      Title: CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR-485-5p/SLC38A1 axis.
    6. Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells.
      Title: Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells.
    7. revealed SLC38A1 as a valuable prognostic and predictive marker for acute myeloid leukemia
      Title: High expression of SLC38A1 predicts poor prognosis in patients with de novo acute myeloid leukemia.
    8. High SNAT1 expression is associated with increased cell migration in breast neoplasms.
      Title: Actin depolymerization mediated loss of SNTA1 phosphorylation and Rac1 activity has implications on ROS production, cell migration and apoptosis.
    9. this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis.
      Title: MicroRNA-593-3p regulates insulin-promoted glucose consumption by targeting Slc38a1 and CLIP3.
    10. Results found that SLC38A1 was up-regulated in colorectal cancer cells (CRC) and significantly associated with tumor invasion and advanced disease stage. Its overexpression enhanced growth and migration of HCT116 cells providing evidence that activation of SLC38A1 may play a critical role in CRC development and progression.
      Title: SLC38A1 promotes proliferation and migration of human colorectal cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC38A1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu degrades SLC38A1 (SNAT1) via the same pathway utilized for antgonism of BST2 (tetherin) but occurs independently of BST2 (tetherin) downregulation PubMed
    vpu HIV-1 Vpu ubiquitinates endogeneous SLC38A1 (SNAT1) in HeLa cells PubMed
    vpu HIV-1 Vpu binds endogeneous SLC38A1 (SNAT1) and is a beta-TrCP-dependent substrate PubMed
    vpu HIV-1 Vpu depletes SLC38A1 (SNAT1) from activated primary human CD4+ T cells in the context of viral infection and as a single gene in transduced cells purified by antibody-free magnetic cell sorting (AFMACS) PubMed
    vpu HIV-1 Vpu downregulates cell (CEMT4) surface expression of SLC38A1 (SNAT1) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-amino acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alanine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amino acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amino acid:sodium symporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables glycine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neutral L-amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proline:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in alanine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter uptake TAS
    Traceable Author Statement
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neutral amino acid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of L-glutamine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic transmission, GABAergic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in external side of apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid symporter 1
    Names
    N-system amino acid transporter 2
    amino acid transporter A1
    amino acid transporter system A1
    sodium-coupled neutral amino acid transporter 1
    system A amino acid transporter 1
    system N amino acid transporter 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077484.2 → NP_001070952.1  sodium-coupled neutral amino acid symporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001070952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AC016254, AK056670, BC010620, BX648495, DB229647
      Consensus CDS
      CCDS41774.1
      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8
      Related
      ENSP00000447853.1, ENST00000546893.5
      Conserved Domains (1) summary
      cl00456
      Location:69 → 474
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001278387.2 → NP_001265316.1  sodium-coupled neutral amino acid symporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001265316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is the longest transcript and encodes the predominant isoform (1). Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AC016254, AC025031, BQ019472, BX647547, BX648495, DB229647
      Consensus CDS
      CCDS41774.1
      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8
      Related
      ENSP00000398142.1, ENST00000439706.5
      Conserved Domains (1) summary
      cl00456
      Location:69 → 474
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001278388.2 → NP_001265317.1  sodium-coupled neutral amino acid symporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001265317.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons in the 5' UTR, compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AC016254, BQ019472, BX648676, DB229647
      Consensus CDS
      CCDS41774.1
      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8
      Related
      ENSP00000449607.1, ENST00000549049.5
      Conserved Domains (1) summary
      cl00456
      Location:69 → 474
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001278389.2 → NP_001265318.1  sodium-coupled neutral amino acid symporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001265318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AC016254, AC025031, AK027825, BC010620, BQ019472
      Consensus CDS
      CCDS41774.1
      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8
      Conserved Domains (1) summary
      cl00456
      Location:69 → 474
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_001278390.1 → NP_001265319.1  sodium-coupled neutral amino acid symporter 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has an alternate 3' terminal exon, compared to variant 3. The resulting isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA740867, AA864710, AK309410
      Consensus CDS
      CCDS61106.1
      UniProtKB/TrEMBL
      F8VX04
      Related
      ENSP00000449756.1, ENST00000552197.5
      Conserved Domains (1) summary
      cl00456
      Location:69 → 480
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. NM_030674.4 → NP_109599.3  sodium-coupled neutral amino acid symporter 1 isoform 1

      See identical proteins and their annotated locations for NP_109599.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an exon in the 5' UTR, compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AC016254, AK056670, BC010620, BX648495, DB229647
      Consensus CDS
      CCDS41774.1
      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8
      Related
      ENSP00000381634.4, ENST00000398637.10
      Conserved Domains (1) summary
      cl00456
      Location:69 → 474
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      46183063..46269043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429588.1 → XP_047285544.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    2. XM_047429598.1 → XP_047285554.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    3. XM_047429591.1 → XP_047285547.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    4. XM_047429597.1 → XP_047285553.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    5. XM_047429594.1 → XP_047285550.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    6. XM_047429592.1 → XP_047285548.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    7. XM_047429589.1 → XP_047285545.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    8. XM_047429593.1 → XP_047285549.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    9. XM_047429595.1 → XP_047285551.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    10. XM_047429590.1 → XP_047285546.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    11. XM_047429596.1 → XP_047285552.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    12. XM_011538784.3 → XP_011537086.1  sodium-coupled neutral amino acid symporter 1 isoform X1

      See identical proteins and their annotated locations for XP_011537086.1

      Conserved Domains (1) summary
      cl00456
      Location:69 → 475
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    13. XM_011538787.3 → XP_011537089.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      See identical proteins and their annotated locations for XP_011537089.1

      UniProtKB/TrEMBL
      Q8NCD8
      Conserved Domains (1) summary
      cl00456
      Location:69 → 456
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    14. XM_011538786.3 → XP_011537088.1  sodium-coupled neutral amino acid symporter 1 isoform X3

      See identical proteins and their annotated locations for XP_011537088.1

      Conserved Domains (2) summary
      COG0814
      Location:68 → 441
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:69 → 454
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    15. XM_047429578.1 → XP_047285534.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    16. XM_047429609.1 → XP_047285565.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    17. XM_047429602.1 → XP_047285558.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    18. XM_047429586.1 → XP_047285542.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    19. XM_047429616.1 → XP_047285572.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    20. XM_047429580.1 → XP_047285536.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    21. XM_047429611.1 → XP_047285567.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    22. XM_047429603.1 → XP_047285559.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    23. XM_047429575.1 → XP_047285531.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    24. XM_017019990.2 → XP_016875479.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8
      Conserved Domains (1) summary
      cl00456
      Location:69 → 456
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    25. XM_047429599.1 → XP_047285555.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    26. XM_047429576.1 → XP_047285532.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    27. XM_047429608.1 → XP_047285564.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    28. XM_047429600.1 → XP_047285556.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    29. XM_047429581.1 → XP_047285537.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    30. XM_047429612.1 → XP_047285568.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    31. XM_047429577.1 → XP_047285533.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    32. XM_047429610.1 → XP_047285566.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    33. XM_047429601.1 → XP_047285557.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    34. XM_047429584.1 → XP_047285540.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    35. XM_047429614.1 → XP_047285570.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    36. XM_047429606.1 → XP_047285562.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    37. XM_047429583.1 → XP_047285539.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    38. XM_047429605.1 → XP_047285561.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    39. XM_047429579.1 → XP_047285535.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    40. XM_047429613.1 → XP_047285569.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    41. XM_047429604.1 → XP_047285560.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    42. XM_047429582.1 → XP_047285538.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    43. XM_047429585.1 → XP_047285541.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    44. XM_047429615.1 → XP_047285571.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    45. XM_047429607.1 → XP_047285563.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    46. XM_047429587.1 → XP_047285543.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      46142659..46228603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373322.1 → XP_054229297.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    2. XM_054373327.1 → XP_054229302.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    3. XM_054373323.1 → XP_054229298.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    4. XM_054373326.1 → XP_054229301.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    5. XM_054373325.1 → XP_054229300.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    6. XM_054373324.1 → XP_054229299.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    7. XM_054373328.1 → XP_054229303.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    8. XM_054373330.1 → XP_054229305.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    9. XM_054373331.1 → XP_054229306.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    10. XM_054373329.1 → XP_054229304.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    11. XM_054373332.1 → XP_054229307.1  sodium-coupled neutral amino acid symporter 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8NC61, Q8NCF8, Q96JX2, Q9H2H9, Q9H2Q2
      UniProtKB/TrEMBL
      Q8NCD8

    12. XM_054373319.1 → XP_054229294.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    13. XM_054373343.1 → XP_054229318.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    14. XM_054373333.1 → XP_054229308.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    15. XM_054373311.1 → XP_054229286.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    16. XM_054373346.1 → XP_054229321.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    17. XM_054373337.1 → XP_054229312.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    18. XM_054373317.1 → XP_054229292.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    19. XM_054373350.1 → XP_054229325.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    20. XM_054373313.1 → XP_054229288.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    21. XM_054373348.1 → XP_054229323.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    22. XM_054373338.1 → XP_054229313.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    23. XM_054373308.1 → XP_054229283.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    24. XM_054373344.1 → XP_054229319.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    25. XM_054373334.1 → XP_054229309.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    26. XM_054373309.1 → XP_054229284.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    27. XM_054373345.1 → XP_054229320.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    28. XM_054373335.1 → XP_054229310.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    29. XM_054373314.1 → XP_054229289.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    30. XM_054373349.1 → XP_054229324.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    31. XM_054373310.1 → XP_054229285.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    32. XM_054373347.1 → XP_054229322.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    33. XM_054373336.1 → XP_054229311.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    34. XM_054373321.1 → XP_054229296.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    35. XM_054373353.1 → XP_054229328.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    36. XM_054373342.1 → XP_054229317.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    37. XM_054373320.1 → XP_054229295.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    38. XM_054373352.1 → XP_054229327.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    39. XM_054373340.1 → XP_054229315.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    40. XM_054373312.1 → XP_054229287.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    41. XM_054373339.1 → XP_054229314.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    42. XM_054373315.1 → XP_054229290.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    43. XM_054373316.1 → XP_054229291.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    44. XM_054373351.1 → XP_054229326.1  sodium-coupled neutral amino acid symporter 1 isoform X4

      UniProtKB/TrEMBL
      Q8NCD8

    45. XM_054373341.1 → XP_054229316.1  sodium-coupled neutral amino acid symporter 1 isoform X3

    46. XM_054373318.1 → XP_054229293.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2H9.1 GenPept UniProtKB/Swiss-Prot:Q9H2H9

    Gene LinkOut

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