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    SPEM1 spermatid maturation 1 [ Homo sapiens (human) ]

    Gene ID: 374768, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPEM1provided by HGNC
    Official Full Name
    spermatid maturation 1provided by HGNC
    Primary source
    HGNC:HGNC:32429
    See related
    Ensembl:ENSG00000181323 MIM:615116; AllianceGenome:HGNC:32429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf83
    Summary
    Predicted to be involved in flagellated sperm motility and sperm individualization. Predicted to act upstream of or within spermatogenesis. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 24.6) See more
    Orthologs
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    Genomic context

    See SPEM1 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7420324..7421632)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7324372..7325680)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7323643..7324951)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8116 Neighboring gene transmembrane protein 256 Neighboring gene neuroligin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7323127-7323646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7329870-7330371 Neighboring gene SPEM family member 2 Neighboring gene SPEM family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    General gene information

    Potential readthrough

    Included gene: FGF11

    Clone Names

    • FLJ40081

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in flagellated sperm motility  
    involved_in sperm individualization  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in membrane  

    General protein information

    Preferred Names
    spermatid maturation protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199339.3NP_955371.2  spermatid maturation protein 1

      See identical proteins and their annotated locations for NP_955371.2

      Status: VALIDATED

      Source sequence(s)
      AC113189, BC033882
      Consensus CDS
      CCDS42254.1
      UniProtKB/Swiss-Prot
      Q8N4L4
      Related
      ENSP00000315554.3, ENST00000323675.4
      Conserved Domains (1) summary
      pfam15670
      Location:46147
      Spem1; Spermatid maturation protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7420324..7421632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_016107299.1 Reference GRCh38.p14 PATCHES

      Range
      40781..42089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7324372..7325680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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