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    MCH2 Mch2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCH2
    Official Full Name
    Mch2p
    Primary source
    SGD:S000001704
    Locus tag
    YKL221W
    See related
    AllianceGenome:SGD:S000001704; FungiDB:YKL221W; VEuPathDB:YKL221W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC16A6 (solute carrier family 16 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MCH2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (6107..7528)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene seripauperin PAU16 Neighboring gene uncharacterized protein Neighboring gene ferric/cupric-chelate reductase Neighboring gene Cos9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. Nelissen B, et al. FEMS Microbiol Rev, 1997 Sep. PMID 9348664
    2. Genome-wide screening of Saccharomyces cerevisiae genes regulated by vanillin. Park EH, et al. J Microbiol Biotechnol, 2015 Jan. PMID 25269814
    3. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
    4. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article
    5. An evolutionarily 'young' lysine residue in histone H3 attenuates transcriptional output in Saccharomyces cerevisiae. Hyland EM, et al. Genes Dev, 2011 Jun 15. PMID 21685365, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mch2p
    NP_012701.2
    • Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      6107..7528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179786.2 → NP_012701.2  TPA: Mch2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012701.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWY2, P36032
      UniProtKB/TrEMBL
      B5VLU4, N1P0L6
      Conserved Domains (1) summary
      cd17352
      Location:41 → 428
      MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36032.2

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