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    MNN11 alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MNN11
    Official Full Name
    alpha-1,6-mannosyltransferase
    Primary source
    SGD:S000003719
    Locus tag
    YJL183W
    See related
    AllianceGenome:SGD:S000003719; FungiDB:YJL183W; VEuPathDB:YJL183W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,6-mannosyltransferase activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MNN11 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (84068..85336)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Atg36p Neighboring gene chromatin DNA-binding EKC/KEOPS complex subunit GON7 Neighboring gene Rbh1p Neighboring gene ATP synthase complex assembly protein ATP12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the MNN10 gene enhances protein secretion in Kluyveromyces lactis and Saccharomyces cerevisiae. Bartkeviciūte D, et al. FEMS Yeast Res, 2004 Sep. PMID 15450190
    2. Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity. Jungmann J, et al. EMBO J, 1998 Jan 15. PMID 9430634, Free PMC Article
    3. Identification of the MNN2 and MNN5 mannosyltransferases required for forming and extending the mannose branches of the outer chain mannans of Saccharomyces cerevisiae. Rayner JC, et al. J Biol Chem, 1998 Oct 9. PMID 9756928
    4. Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity. Lien EC, et al. Biochemistry, 2013 Jan 8. PMID 23210626, Free PMC Article
    5. Interaction among the subunits of Golgi membrane mannosyltransferase complexes of the yeast Saccharomyces cerevisiae. Kojima H, et al. Biosci Biotechnol Biochem, 1999 Nov. PMID 10635561

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    part_of mannan polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mannan polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,6-mannosyltransferase
    NP_012352.2
    • Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      84068..85336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181616.2 → NP_012352.2  TPA: alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012352.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW07, E9P8Z0, P46985
      UniProtKB/TrEMBL
      A6ZQF2, B3LPU3, B5VL08, C8ZB36, G2WGJ3, N1P3S7
      Conserved Domains (1) summary
      pfam05637
      Location:156 → 408
      Glyco_transf_34; galactosyl transferase GMA12/MNN10 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46985.2

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