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    PHO90 SPX domain-containing inorganic phosphate transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PHO90
    Official Full Name
    SPX domain-containing inorganic phosphate transporter
    Primary source
    SGD:S000003734
    Locus tag
    YJL198W
    See related
    AllianceGenome:SGD:S000003734; FungiDB:YJL198W; VEuPathDB:YJL198W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphate transmembrane transporter activity. Involved in phosphate ion transport; polyphosphate metabolic process; and regulation of phosphate transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A1 (solute carrier family 13 member 1); SLC13A2 (solute carrier family 13 member 2); and SLC13A4 (solute carrier family 13 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PHO90 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (60844..63489)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Mbb1p Neighboring gene putative ubiquitin-specific protease UBP12 Neighboring gene fatty acid elongase ELO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism. Schneider S, et al. Structure, 2024 Jul 11. PMID 38688287
    2. Budding yeast escape commitment to the phosphate starvation program using gene expression noise. Vardi N, et al. Curr Biol, 2013 Oct 21. PMID 24094854
    3. The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity. Hürlimann HC, et al. EMBO Rep, 2009 Sep. PMID 19590579, Free PMC Article
    4. Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae. Auesukaree C, et al. Biochem Biophys Res Commun, 2003 Jul 11. PMID 12821119
    5. Inhibition of the protein kinase A alters the degradation of the high-affinity phosphate transporter Pho84 in Saccharomyces cerevisiae. Mouillon JM, et al. Curr Genet, 2005 Oct. PMID 16160831

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism.
      Title: Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism.
    2. Pho90 represent non-redundant P(i) transporters, which are tuned by the integration of multiple nutrient signalling mechanisms in order to adjust P(i)-transport capacity to the general nutritional status of the environment.
      Title: Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae.
    3. SPX domain of Pho90 limits the phosphate-uptake velocity, suppresses phosphate efflux and affects the regulation of the phosphate signal transduction pathway.
      Title: The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphate ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phosphate transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SPX domain-containing inorganic phosphate transporter
    NP_012337.1
    • Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      60844..63489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181631.1 → NP_012337.1  TPA: SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39535
      UniProtKB/TrEMBL
      G2WGI0
      Conserved Domains (2) summary
      COG5408
      Location:1 → 288
      COG5408; SPX domain-containing protein [Signal transduction mechanisms]
      cd01115
      Location:442 → 870
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39535.1

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