MAST4 microtubule associated serine/threonine kinase family member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAST4provided by HGNC
Official Full Name: microtubule associated serine/threonine kinase family member 4provided by HGNC
Primary source: HGNC:HGNC:19037
See related: Ensembl:ENSG00000069020 MIM:618002; AllianceGenome:HGNC:19037
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Expression: Ubiquitous expression in esophagus (RPKM 3.2), fat (RPKM 2.7) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q12.3

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (66596393..67169593)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (67418473..67991744)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (65892221..66465421)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
Title: MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
Nuclear MAST4 Suppresses FOXO3 through Interaction with AKT3 and Induces Chemoresistance in Pancreatic Ductal Carcinoma.
Title: Nuclear MAST4 Suppresses FOXO3 through Interaction with AKT3 and Induces Chemoresistance in Pancreatic Ductal Carcinoma.
Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease.
Title: Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease.
Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
Title: Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
Molecular studies incriminated different genes, mainly CACNA1H and MAST4. Since at least 2 susceptibility genes were likely shared by different populations, genetic factors involved in the majority of Tunisian Genetic generalized epilepsies families remain to be discovered.
Title: Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
high expression level of MAST4 in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte.
Title: [Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family].

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32 EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-68613 (e-PCR)
- UniSTS:95488

RH123041 (e-PCR)
- UniSTS:135430

SHGC-153316 (e-PCR)
- UniSTS:177671

D5S647 (e-PCR)
- UniSTS:44568

SHGC-13353 (e-PCR)
- UniSTS:50471

SHGC-142653 (e-PCR)
- UniSTS:171573

RH99012 (e-PCR)
- UniSTS:84810

RH65868 (e-PCR)
- UniSTS:86

RH119738 (e-PCR)
- UniSTS:133214

G62906 (e-PCR)
- UniSTS:139881

D5S2697 (e-PCR)
- UniSTS:28009

D5S2089 (e-PCR), detects polymorphism
- UniSTS:28789

RH36905 (e-PCR)
- UniSTS:87932

SHGC-82627 (e-PCR)
- UniSTS:95614

LOC375449 (e-PCR)
- UniSTS:505734

RH80944 (e-PCR)
- UniSTS:93063

bac55085T (e-PCR)
- UniSTS:181639

AB056382 (e-PCR)
- UniSTS:479888

G59014 (e-PCR)
- UniSTS:136338

SHGC-58481 (e-PCR)
- UniSTS:94361

L28229 (e-PCR)
- UniSTS:7579

AFMA296ZE5 (e-PCR)
- UniSTS:67745

D5S647 (e-PCR)
- UniSTS:51876

KT3 (e-PCR)
- UniSTS:241079

KT4T3 (e-PCR)
- UniSTS:241080

KT4T7 (e-PCR)
- UniSTS:241081

KT5T3 (e-PCR)
- UniSTS:241082

KT5T7 (e-PCR)
- UniSTS:241083

L31437 (e-PCR)
- UniSTS:60091

KTB12L (e-PCR)
- UniSTS:241084

KTB12R (e-PCR)
- UniSTS:241085

RH47992 (e-PCR)
- UniSTS:66500

D5S2072 (e-PCR), detects polymorphism
- UniSTS:47301

SHGC-106144 (e-PCR)
- UniSTS:169676

L28398 (e-PCR)
- UniSTS:63197

SHGC-82470 (e-PCR)
- UniSTS:104436

SHGC-143417 (e-PCR)
- UniSTS:174079

Clone Names

FLJ16540, FLJ33039, KIAA0303, DKFZp686N1467, DKFZp686E18148

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 4

NP_001158136.1

EC 2.7.11.1

NP_001277155.1

EC 2.7.11.1

NP_001277156.1

EC 2.7.11.1

NP_001277157.1

EC 2.7.11.1

NP_001284580.1

EC 2.7.11.1

NP_001380453.1

EC 2.7.11.1

NP_001380454.1

EC 2.7.11.1

NP_001380455.1

EC 2.7.11.1

NP_001380456.1

EC 2.7.11.1

NP_001380457.1

EC 2.7.11.1

NP_055998.1

EC 2.7.11.1

NP_942123.1

EC 2.7.11.1

XP_006714669.1

EC 2.7.11.1

XP_011541686.1

EC 2.7.11.1

XP_011541687.1

EC 2.7.11.1

XP_011541688.1

EC 2.7.11.1

XP_016864938.1

EC 2.7.11.1

XP_016864939.1

EC 2.7.11.1

XP_016864941.1

EC 2.7.11.1

XP_016864942.1

EC 2.7.11.1

XP_024301812.1

EC 2.7.11.1

XP_047273113.1

EC 2.7.11.1

XP_047273114.1

EC 2.7.11.1

XP_047273115.1

EC 2.7.11.1

XP_047273116.1

EC 2.7.11.1

XP_047273117.1

EC 2.7.11.1

XP_047273118.1

EC 2.7.11.1

XP_047273119.1

EC 2.7.11.1

XP_047273120.1

EC 2.7.11.1

XP_047273121.1

EC 2.7.11.1

XP_054208513.1

EC 2.7.11.1

XP_054208514.1

EC 2.7.11.1

XP_054208515.1

EC 2.7.11.1

XP_054208516.1

EC 2.7.11.1

XP_054208517.1

EC 2.7.11.1

XP_054208518.1

EC 2.7.11.1

XP_054208519.1

EC 2.7.11.1

XP_054208520.1

EC 2.7.11.1

XP_054208521.1

EC 2.7.11.1

XP_054208522.1

EC 2.7.11.1

XP_054208523.1

EC 2.7.11.1

XP_054208524.1

EC 2.7.11.1

XP_054208525.1

EC 2.7.11.1

XP_054208526.1

EC 2.7.11.1

XP_054208527.1

EC 2.7.11.1

XP_054208528.1

EC 2.7.11.1

XP_054208529.1

EC 2.7.11.1

XP_054208530.1

EC 2.7.11.1

XP_054208531.1

EC 2.7.11.1

XP_054208532.1

EC 2.7.11.1

XP_054208533.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_034036.1 RefSeqGene

Range

5046..578246

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001164664.2 → NP_001158136.1 microtubule-associated serine/threonine-protein kinase 4 isoform 3

Status: REVIEWED

Source sequence(s)

AC008872, AC008920, AC016634, AC044799, AC092373

Consensus CDS

CCDS54861.1

UniProtKB/Swiss-Prot

A6NL49, B5ME48, E7EWQ5, J3QT34, O15021, Q05EE6, Q6ZN07, Q8N4X4, Q96LY3

Related

ENSP00000385727.1, ENST00000403625.7

Conserved Domains (4) summary

cd00992
Location:1146 → 1224

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:569 → 848

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:258 → 531

DUF1908; Domain of unknown function (DUF1908)

cl26464
Location:1811 → 2189

Atrophin-1; Atrophin-1 family
NM_001290226.2 → NP_001277155.1 microtubule-associated serine/threonine-protein kinase 4 isoform 4

Status: REVIEWED

Source sequence(s)

AB002301, AC044799, AK299538

UniProtKB/Swiss-Prot

O15021

UniProtKB/TrEMBL

B4DS23

Conserved Domains (4) summary

smart00220
Location:364 → 637

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:940 → 1018

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:363 → 642

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:49 → 325

DUF1908; Domain of unknown function (DUF1908)
NM_001290227.2 → NP_001277156.1 microtubule-associated serine/threonine-protein kinase 4 isoform 5

Status: REVIEWED

Source sequence(s)

AC044799, AK296707

UniProtKB/TrEMBL

B4DKT8

Conserved Domains (4) summary

PHA03247
Location:1550 → 1928

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:885 → 963

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)
NM_001290228.2 → NP_001277157.1 microtubule-associated serine/threonine-protein kinase 4 isoform 6

Status: REVIEWED

Source sequence(s)

AC008872, AC092373, AY439222, BC033215, CB044105

Consensus CDS

CCDS78015.1

UniProtKB/TrEMBL

E7EX28, Q6T2V4

Related

ENSP00000384547.1, ENST00000406039.5
NM_001297651.2 → NP_001284580.1 microtubule-associated serine/threonine-protein kinase 4 isoform 7

Status: REVIEWED

Source sequence(s)

AC044799, AK057601, AK299706, AY830839, BF515864

Consensus CDS

CCDS75254.1

UniProtKB/Swiss-Prot

O15021

UniProtKB/TrEMBL

B4DSE5

Related

ENSP00000261569.7, ENST00000261569.11

Conserved Domains (4) summary

smart00220
Location:376 → 649

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:952 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)
NM_001393524.1 → NP_001380453.1 microtubule-associated serine/threonine-protein kinase 4 isoform 8

Status: REVIEWED

Source sequence(s)

AC008872, AC008920, AC016634, AC044799, AC092373

Conserved Domains (3) summary

PHA03247
Location:1814 → 2192

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:1149 → 1227

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:572 → 851

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
NM_001393525.1 → NP_001380454.1 microtubule-associated serine/threonine-protein kinase 4 isoform 9

Status: REVIEWED

Source sequence(s)

AC008872, AC008920, AC016634, AC044799, AC092373

Conserved Domains (3) summary

PHA03247
Location:1744 → 2122

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:1079 → 1157

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:569 → 848

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
NM_001393526.1 → NP_001380455.1 microtubule-associated serine/threonine-protein kinase 4 isoform 10

Status: REVIEWED

Source sequence(s)

AC008872, AC008920, AC016634, AC044799

Conserved Domains (3) summary

PHA03247
Location:1555 → 1933

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:890 → 968

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:380 → 659

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
NM_001393527.1 → NP_001380456.1 microtubule-associated serine/threonine-protein kinase 4 isoform 5

Status: REVIEWED

Source sequence(s)

AC008872, AC008920, AC044799

Conserved Domains (4) summary

PHA03247
Location:1550 → 1928

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:885 → 963

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)
NM_001393528.1 → NP_001380457.1 microtubule-associated serine/threonine-protein kinase 4 isoform 12

Status: REVIEWED

Source sequence(s)

AC008872, AC008920, AC016634, AC044799

Conserved Domains (4) summary

PHA03247
Location:1543 → 1921

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:878 → 956

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:57 → 330

DUF1908; Domain of unknown function (DUF1908)
NM_015183.3 → NP_055998.1 microtubule-associated serine/threonine-protein kinase 4 isoform 1

Status: REVIEWED

Source sequence(s)

AC016634, AC044799, AY830839

Consensus CDS

CCDS47225.1

UniProtKB/Swiss-Prot

O15021

Related

ENSP00000384313.1, ENST00000403666.5

Conserved Domains (4) summary

smart00220
Location:381 → 654

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:957 → 1035

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:380 → 659

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:69 → 342

DUF1908; Domain of unknown function (DUF1908)
NM_198828.3 → NP_942123.1 microtubule-associated serine/threonine-protein kinase 4 isoform 2

Status: REVIEWED

Source sequence(s)

BC033215

Consensus CDS

CCDS47224.1

UniProtKB/TrEMBL

Q6T2V4

Related

ENSP00000385088.1, ENST00000406374.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

66596393..67169593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024446044.2 → XP_024301812.1 microtubule-associated serine/threonine-protein kinase 4 isoform X1

Conserved Domains (4) summary

cd00992
Location:1218 → 1296

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:641 → 920

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:330 → 603

DUF1908; Domain of unknown function (DUF1908)

cl26464
Location:1883 → 2261

Atrophin-1; Atrophin-1 family
XM_047417157.1 → XP_047273113.1 microtubule-associated serine/threonine-protein kinase 4 isoform X2
XM_047417158.1 → XP_047273114.1 microtubule-associated serine/threonine-protein kinase 4 isoform X3
XM_047417159.1 → XP_047273115.1 microtubule-associated serine/threonine-protein kinase 4 isoform X4
XM_047417160.1 → XP_047273116.1 microtubule-associated serine/threonine-protein kinase 4 isoform X5
XM_017009452.2 → XP_016864941.1 microtubule-associated serine/threonine-protein kinase 4 isoform X15
XM_017009450.2 → XP_016864939.1 microtubule-associated serine/threonine-protein kinase 4 isoform X9
XM_047417164.1 → XP_047273120.1 microtubule-associated serine/threonine-protein kinase 4 isoform X15
XM_017009449.2 → XP_016864938.1 microtubule-associated serine/threonine-protein kinase 4 isoform X6

Related

ENSP00000384099.1, ENST00000405643.5
XM_047417161.1 → XP_047273117.1 microtubule-associated serine/threonine-protein kinase 4 isoform X12
XM_011543385.4 → XP_011541687.1 microtubule-associated serine/threonine-protein kinase 4 isoform X10

Conserved Domains (4) summary

smart00220
Location:361 → 634

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:937 → 1015

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:360 → 639

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:49 → 322

DUF1908; Domain of unknown function (DUF1908)
XM_047417163.1 → XP_047273119.1 microtubule-associated serine/threonine-protein kinase 4 isoform X14
XM_006714606.4 → XP_006714669.1 microtubule-associated serine/threonine-protein kinase 4 isoform X7

UniProtKB/Swiss-Prot

O15021

Conserved Domains (4) summary

smart00220
Location:376 → 649

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:952 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)
XM_047417165.1 → XP_047273121.1 microtubule-associated serine/threonine-protein kinase 4 isoform X15
XM_017009453.2 → XP_016864942.1 microtubule-associated serine/threonine-protein kinase 4 isoform X15
XM_011543386.3 → XP_011541688.1 microtubule-associated serine/threonine-protein kinase 4 isoform X11

Conserved Domains (4) summary

smart00220
Location:358 → 631

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:934 → 1012

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:357 → 636

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:46 → 319

DUF1908; Domain of unknown function (DUF1908)
XM_011543384.3 → XP_011541686.1 microtubule-associated serine/threonine-protein kinase 4 isoform X8

Conserved Domains (4) summary

smart00220
Location:370 → 643

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:946 → 1024

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:369 → 648

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:58 → 331

DUF1908; Domain of unknown function (DUF1908)
XM_047417162.1 → XP_047273118.1 microtubule-associated serine/threonine-protein kinase 4 isoform X13

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

67418473..67991744

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352538.1 → XP_054208513.1 microtubule-associated serine/threonine-protein kinase 4 isoform X1
XM_054352539.1 → XP_054208514.1 microtubule-associated serine/threonine-protein kinase 4 isoform X2
XM_054352540.1 → XP_054208515.1 microtubule-associated serine/threonine-protein kinase 4 isoform X3
XM_054352541.1 → XP_054208516.1 microtubule-associated serine/threonine-protein kinase 4 isoform X4
XM_054352542.1 → XP_054208517.1 microtubule-associated serine/threonine-protein kinase 4 isoform X5
XM_054352547.1 → XP_054208522.1 microtubule-associated serine/threonine-protein kinase 4 isoform X9
XM_054352543.1 → XP_054208518.1 microtubule-associated serine/threonine-protein kinase 4 isoform X6
XM_054352550.1 → XP_054208525.1 microtubule-associated serine/threonine-protein kinase 4 isoform X12
XM_054352548.1 → XP_054208523.1 microtubule-associated serine/threonine-protein kinase 4 isoform X10
XM_054352556.1 → XP_054208531.1 microtubule-associated serine/threonine-protein kinase 4 isoform X14
XM_054352551.1 → XP_054208526.1 microtubule-associated serine/threonine-protein kinase 4 isoform X16
XM_054352553.1 → XP_054208528.1 microtubule-associated serine/threonine-protein kinase 4 isoform X16
XM_054352552.1 → XP_054208527.1 microtubule-associated serine/threonine-protein kinase 4 isoform X16
XM_054352554.1 → XP_054208529.1 microtubule-associated serine/threonine-protein kinase 4 isoform X16
XM_054352545.1 → XP_054208520.1 microtubule-associated serine/threonine-protein kinase 4 isoform X7
XM_054352544.1 → XP_054208519.1 microtubule-associated serine/threonine-protein kinase 4 isoform X7
XM_054352557.1 → XP_054208532.1 microtubule-associated serine/threonine-protein kinase 4 isoform X15
XM_054352558.1 → XP_054208533.1 microtubule-associated serine/threonine-protein kinase 4 isoform X15
XM_054352549.1 → XP_054208524.1 microtubule-associated serine/threonine-protein kinase 4 isoform X11
XM_054352546.1 → XP_054208521.1 microtubule-associated serine/threonine-protein kinase 4 isoform X8
XM_054352555.1 → XP_054208530.1 microtubule-associated serine/threonine-protein kinase 4 isoform X13