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    RIX1 Rix1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIX1
    Official Full Name
    Rix1p
    Primary source
    SGD:S000001240
    Locus tag
    YHR197W
    See related
    AllianceGenome:SGD:S000001240; FungiDB:YHR197W; VEuPathDB:YHR197W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    IPI2
    Summary
    Enables chromatin binding activity. Involved in pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-templated DNA replication initiation; and ribosome biogenesis. Located in cytosol and nucleoplasm. Part of rixosome complex. Orthologous to human PELP1 (proline, glutamate and leucine rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RIX1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (493896..496187)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Nvj1p Neighboring gene Utp9p Neighboring gene Aim18p Neighboring gene Aim46p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. Kater L, et al. Mol Cell, 2020 Aug 20. PMID 32668200
    2. Chemical Genomic Profiling Unveils the in Vitro and in Vivo Antiplasmodial Mechanism of Açaí (Euterpe oleracea Mart.) Polyphenols. Ferreira LT, et al. ACS Omega, 2019 Sep 24. PMID 31572864, Free PMC Article
    3. Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits. Galani K, et al. J Biol Chem, 2004 Dec 31. PMID 15528184
    4. Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p. Gadal O, et al. Mol Cell Biol, 2001 May. PMID 11313466, Free PMC Article
    5. The yeast kinase Swe1 is required for proper entry into cell cycle after arrest due to ribosome biogenesis and protein synthesis defects. Saracino F, et al. Cell Cycle, 2004 May. PMID 15107621

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.
      Title: Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.
    2. study identified the Rix1 complex members (Ipi1p-Ipi2p/Rix1-Ipi3p) as pre-replicative complex components and critical determinants of replication licensing and replication-initiation frequency
      Title: The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of rixosome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rix1p
    NP_012067.4
    • Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      493896..496187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179328.4 → NP_012067.4  TPA: Rix1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012067.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLE5, P38883
      UniProtKB/TrEMBL
      B5VKC5, N1P1C3
      Conserved Domains (1) summary
      pfam08167
      Location:8 → 201
      RIX1; rRNA processing/ribosome biogenesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38883.2

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