U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GAR1 H/ACA snoRNP pseudouridylase subunit GAR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856489, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GAR1
    Official Full Name
    H/ACA snoRNP pseudouridylase subunit GAR1
    Primary source
    SGD:S000001131
    Locus tag
    YHR089C
    See related
    AllianceGenome:SGD:S000001131; FungiDB:YHR089C; VEuPathDB:YHR089C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables box H/ACA snoRNA binding activity. Involved in snRNA pseudouridine synthesis. Located in nucleolus. Part of box H/ACA snoRNP complex. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GAR1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (282681..283298, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rtc3p Neighboring gene rRNA-binding ribosome biosynthesis protein RPF1 Neighboring gene histone acetyltransferase YNG2 Neighboring gene arginine--tRNA ligase MSR1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a segment of the small nucleolar ribonucleoprotein-associated protein GAR1 that is sufficient for nucleolar accumulation. Girard JP, et al. J Biol Chem, 1994 Jul 15. PMID 8034598
    2. A small nucleolar RNP protein is required for pseudouridylation of eukaryotic ribosomal RNAs. Bousquet-Antonelli C, et al. EMBO J, 1997 Aug 1. PMID 9303321, Free PMC Article
    3. Gar1p binds to the small nucleolar RNAs snR10 and snR30 in vitro through a nontypical RNA binding element. Bagni C, et al. J Biol Chem, 1998 May 1. PMID 9556561
    4. Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. Peifer C, et al. Nucleic Acids Res, 2013 Jan. PMID 23180764, Free PMC Article
    5. GAR1 is an essential small nucleolar RNP protein required for pre-rRNA processing in yeast. Girard JP, et al. EMBO J, 1992 Feb. PMID 1531632, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studied and discovered 21 native sites of arginine methylation on five putative Hmt1 substrate proteins (Gar1p, Nop1p, Npl3p, Nsr1p, Rps2p).
      Title: Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p.
    2. box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p
      Title: The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables box H/ACA snoRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snoRNA guided rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    H/ACA snoRNP pseudouridylase subunit GAR1
    NP_011957.1
    • Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      282681..283298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179219.1 → NP_011957.1  TPA: H/ACA snoRNP pseudouridylase subunit GAR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL41, P28007
      UniProtKB/TrEMBL
      A6ZSZ9, B3LSK7, B5VK20, C7GWV3, C8Z9N4, G2WFG4, N1P2P9
      Conserved Domains (1) summary
      pfam04410
      Location:29 → 124
      Gar1; Gar1/Naf1 RNA binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28007.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools