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    PRP38 U4/U6-U5 snRNP complex subunit PRP38 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRP38
    Official Full Name
    U4/U6-U5 snRNP complex subunit PRP38
    Primary source
    SGD:S000003307
    Locus tag
    YGR075C
    See related
    AllianceGenome:SGD:S000003307; FungiDB:YGR075C; VEuPathDB:YGR075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Part of U4/U6 x U5 tri-snRNP complex. Used to study cancer. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRP38 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (636147..636875, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Env11p Neighboring gene Upf3p Neighboring gene mRNA splicing protein SMD1 Neighboring gene mitochondrial 54S ribosomal protein YmL25 Neighboring gene Pex8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Blanton S, et al. Mol Cell Biol, 1992 Sep. PMID 1508195, Free PMC Article
    2. Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. Xie J, et al. EMBO J, 1998 May 15. PMID 9582287, Free PMC Article
    3. Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation. Lybarger S, et al. Mol Cell Biol, 1999 Jan. PMID 9858581, Free PMC Article
    4. Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor. Ulrich AK, et al. BMC Evol Biol, 2017 Mar 24. PMID 28335716, Free PMC Article
    5. Inhibition of a spliceosome turnover pathway suppresses splicing defects. Pandit S, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16945917, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit PRP38
    NP_011589.3
    • Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      636147..636875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181204.3 → NP_011589.3  TPA: U4/U6-U5 snRNP complex subunit PRP38 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011589.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUK7, Q00723
      UniProtKB/TrEMBL
      A6ZV57, B3LIF1, B5VJ21, C7GXQ4, C8Z8W9, G2WEF9, N1P3X3
      Conserved Domains (1) summary
      pfam03371
      Location:15 → 211
      PRP38; PRP38 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00723.1

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