HOM3 aspartate kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HOM3
Official Full Name: aspartate kinase
Primary source: SGD:S000000854
Locus tag: YER052C
See related: AllianceGenome:SGD:S000000854; FungiDB:YER052C; VEuPathDB:YER052C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BOR1; SIL4; THR3
Summary: Enables aspartate kinase activity. Involved in homoserine biosynthetic process; methionine biosynthetic process; and threonine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HOM3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (256375..257958, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aspartate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartate kinase activity	IEA Inferred from Electronic Annotation more info
enables aspartate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alpha-amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in homoserine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in homoserine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methionine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in threonine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in threonine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in threonine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aspartate kinase

NP_010972.1

EC 2.7.2.4

Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; subject to allosteric feedback inhibition by threonine; expression regulated by Gcn4p and the general control of amino acid synthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

256375..257958 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178943.1 → NP_010972.1 TPA: aspartate kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010972.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLV4, P10869

UniProtKB/TrEMBL

A6ZR03, B3LS65, C7GSK1, C8Z756, G2WCT7, N1P4U6

Conserved Domains (3) summary

cd04919
Location:437 → 502

ACT_AK-Hom3_2; ACT domains located C-terminal to the catalytic domain of the aspartokinase (AK) HOM3

cd04934
Location:362 → 435

ACT_AK-Hom3_1; CT domains located C-terminal to the catalytic domain of the aspartokinase (AK) HOM3, a monofunctional class enzyme found in Saccharomyces cerevisiae, and other related ACT domains

cd04247
Location:13 → 324

AAK_AK-Hom3; Amino Acid Kinase Superfamily (AAK), AK-Hom3; this CD includes the N-terminal catalytic domain of the aspartokinase HOM3, a monofunctional class enzyme found in Saccharomyces cerevisiae and other related AK domains. Aspartokinase, the first enzyme in the ...