TAF5 chromatin modification protein [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TAF5
Official Full Name: chromatin modification protein
Primary source: SGD:S000000402
Locus tag: YBR198C
See related: AllianceGenome:SGD:S000000402; FungiDB:YBR198C; VEuPathDB:YBR198C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TAF90
Summary: Enables chromatin binding activity; molecular adaptor activity; and ubiquitin binding activity. Involved in chromatin organization and transcription by RNA polymerase II. Part of SAGA complex; SLIK (SAGA-like) complex; and transcription factor TFIID complex. Orthologous to several human genes including TAF5 (TATA-box binding protein associated factor 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TAF5 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (616127..618523, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that the N-terminal sub-domain of the TAF(II)5 N terminus dimerizes at very high concentration but is neither required for yeast viability, nor for incorporation of two TAF(II)5 molecules within TFIID and for the assembly of this complex.
Title: Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SLIK (SAGA-like) complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chromatin modification protein

NP_009757.1

Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

616127..618523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178546.1 → NP_009757.1 TPA: chromatin modification protein [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009757.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQJ4, P38129

UniProtKB/TrEMBL

B3LMW2, B5VEE8, C7GKF9, D3UEU4, G2W9K1

Conserved Domains (4) summary

smart00667
Location:55 → 88

LisH; Lissencephaly type-1-like homology motif

cd00200
Location:458 → 722

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:470 → 523

7WD40; WD40 repeat [structural motif]

pfam04494
Location:149 → 275

TFIID_NTD2; WD40 associated region in TFIID subunit, NTD2 domain