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    CMD1 calmodulin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CMD1
    Official Full Name
    calmodulin
    Primary source
    SGD:S000000313
    Locus tag
    YBR109C
    See related
    AllianceGenome:SGD:S000000313; FungiDB:YBR109C; VEuPathDB:YBR109C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables calcium ion binding activity; calcium-dependent protein binding activity; and mitogen-activated protein kinase binding activity. Involved in several processes, including cellular hyperosmotic response; organelle fusion; and protein import into nucleus. Located in several cellular components, including cellular bud tip; central plaque of spindle pole body; and incipient cellular bud site. Used to study cancer. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; familial hypertrophic cardiomyopathy; long QT syndrome 14; long QT syndrome 15; and long QT syndrome 16. Orthologous to several human genes including CALM1 (calmodulin 1); CALM2 (calmodulin 2); and CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CMD1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (457919..458362, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Iml3p Neighboring gene Aim3p Neighboring gene chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase Neighboring gene ADP-ribose diphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ca(2+)-dependent ubiquitination of calmodulin in yeast. Jennissen HP, et al. FEBS Lett, 1992 Jan 13. PMID 1309706
    2. Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Peters C, et al. Nature, 1998 Dec 10. PMID 9859992
    3. A strange calmodulin of yeast. Yazawa M, et al. Mol Cell Biochem, 1999 Jan. PMID 10098968
    4. The whole is not the simple sum of its parts in calmodulin from S. cerevisiae. Lee SY, et al. Biochemistry, 2000 Apr 18. PMID 10757969
    5. A genetic analysis of the role of calcineurin and calmodulin in Ca++-dependent improvement of NaCl tolerance of Saccharomyces cerevisiae. Danielsson A, et al. Curr Genet, 1996 Dec. PMID 8939808

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
      Title: Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
    2. Concomitantly, calmodulin dissociation triggered Myo5 binding to Vrp1, extended the myosin-I lifespan at endocytic sites and activated Myo5-induced actin polymerization.
      Title: Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites.
    3. Microautophagic vacuole invagination requires CMD1 in a Ca2+-independent function.
      Title: Microautophagic vacuole invagination requires calmodulin in a Ca2+-independent function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell budding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane tubulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spindle pole body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle pole body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud HDA PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in central plaque of spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in central plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin
    NP_009667.1
    • Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      457919..458362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178457.1 → NP_009667.1  TPA: calmodulin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009667.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQA8, P06787
      UniProtKB/TrEMBL
      A6ZL54, B3LN44, C7GUK7, D3UEK2, G2W9B4, N1P860
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 145
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06787.1

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