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    LAA2 Laa2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852273, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LAA2
    Official Full Name
    Laa2p
    Primary source
    SGD:S000000106
    Locus tag
    YBL010C
    See related
    AllianceGenome:SGD:S000000106; FungiDB:YBL010C; VEuPathDB:YBL010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within clathrin-coated vesicle cargo loading, AP-1-mediated and protein-containing complex localization. Located in clathrin-coated vesicle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LAA2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (206107..206949, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene methionyl-tRNA formyltransferase Neighboring gene bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 Neighboring gene protein kinase ALK2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast. Zysnarski CJ, et al. J Biol Chem, 2019 Jan 25. PMID 30523155, Free PMC Article
    2. Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism. Schmidt O, et al. EMBO J, 2019 Aug 1. PMID 31368600, Free PMC Article
    3. Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Graumann J, et al. Mol Cell Proteomics, 2004 Mar. PMID 14660704
    4. A protein interaction map of the mitotic spindle. Wong J, et al. Mol Biol Cell, 2007 Oct. PMID 17634282, Free PMC Article
    5. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within clathrin-coated vesicle cargo loading, AP-1-mediated IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein-containing complex localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle HDA PubMed 
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Laa2p
    NP_009543.1
    • Clathrin adaptor (adaptin) accessory protein; physically interacts with and is involved in localization of clathrin adaptor protein complex-1 (AP-1); green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      206107..206949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178250.1 → NP_009543.1  TPA: Laa2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPY9, P32788
      UniProtKB/TrEMBL
      A6ZKT7, B3LNE9, C8Z3Y6, G2W8Z8, N1P7F8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32788.1

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