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    THP3 Thp3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THP3
    Official Full Name
    Thp3p
    Primary source
    SGD:S000006249
    Locus tag
    YPR045C
    See related
    AllianceGenome:SGD:S000006249; FungiDB:YPR045C; VEuPathDB:YPR045C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mRNA splicing, via spliceosome. Located in euchromatin. Orthologous to human LENG8 (leukocyte receptor cluster member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THP3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (655140..656552, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Puf2p Neighboring gene ribosomal 60S subunit protein L43A Neighboring gene Mcm16p Neighboring gene phenylalanine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing. Kuang Z, et al. Nucleic Acids Res, 2022 Aug 26. PMID 35904806, Free PMC Article
    2. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Jimeno S, et al. Mol Cell Biol, 2011 Feb. PMID 21149575, Free PMC Article
    3. Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152. Katta SS, et al. Genetics, 2015 Dec. PMID 26510791, Free PMC Article
    4. A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. Choi J, et al. PLoS One, 2017. PMID 28520786, Free PMC Article
    5. Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Measday V, et al. Proc Natl Acad Sci U S A, 2005 Sep 27. PMID 16172405, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role in transcription elongation for Ypr045c (Thp3) and the Csn12 component of the COP9 signalosome
      Title: New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thp3p
    NP_015370.1
    • Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      655140..656552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184142.1 → NP_015370.1  TPA: Thp3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W453, Q07109, Q12049
      UniProtKB/TrEMBL
      A6ZWT6, B3LLA3, C7GY34, C8ZJ70, G2WPM1, N1P239
      Conserved Domains (1) summary
      cl24019
      Location:206 → 424
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12049.1

    Gene LinkOut

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