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    SUT2 Sut2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SUT2
    Official Full Name
    Sut2p
    Primary source
    SGD:S000006213
    Locus tag
    YPR009W
    See related
    AllianceGenome:SGD:S000006213; FungiDB:YPR009W; VEuPathDB:YPR009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including positive regulation of induction of conjugation with cellular fusion; positive regulation of sterol import; and regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SUT2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (576552..577358)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Haa1p Neighboring gene DNA-directed RNA polymerase I core subunit RPA135 Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells. Ness F, et al. Eur J Biochem, 2001 Mar. PMID 11248676
    2. SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast. Rützler M, et al. Eur J Biochem, 2004 Apr. PMID 15030478
    3. Regulation of mating in the budding yeast Saccharomyces cerevisiae by the zinc cluster proteins Sut1 and Sut2. Blanda C, et al. Biochem Biophys Res Commun, 2013 Aug 16. PMID 23872066
    4. The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways. Woods K, et al. Mol Microbiol, 2016 Feb. PMID 26448198
    5. High-resolution DNA-binding specificity analysis of yeast transcription factors. Zhu C, et al. Genome Res, 2009 Apr. PMID 19158363, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of filamentous growth of a population of unicellular organisms IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of induction of conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sterol import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sut2p
    NP_015334.1
    • Zn2Cys6 family transcription factor; positively regulates sterol uptake under anaerobic conditions with SUT1; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; multicopy suppressor of mutations that cause low activity of the cAMP/PKA pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      576552..577358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184106.1 → NP_015334.1  TPA: Sut2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015334.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W420, Q12286
      UniProtKB/TrEMBL
      B5VTH0, C7GV34, C8ZJ34, N1NW02
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12286.1

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