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    GPR82 G protein-coupled receptor 82 [ Homo sapiens (human) ]

    Gene ID: 27197, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPR82provided by HGNC
    Official Full Name
    G protein-coupled receptor 82provided by HGNC
    Primary source
    HGNC:HGNC:4533
    See related
    Ensembl:ENSG00000171657 MIM:300748; AllianceGenome:HGNC:4533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]
    Expression
    Broad expression in lymph node (RPKM 1.4), appendix (RPKM 1.3) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR82 in Genome Data Viewer
    Location:
    Xp11.4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (41724181..41730130)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (41129121..41135070)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (41583434..41589383)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene RNA, 7SL, cytoplasmic 144, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41570764-41571264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41571265-41571765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:41577964-41578464 Neighboring gene G protein-coupled receptor 34 Neighboring gene ribosomal protein S15a pseudogene 39 Neighboring gene NANOG hESC enhancer GRCh37_chrX:41662134-41662675 Neighboring gene RNA, U6 small nuclear 202, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Discovery and mapping of ten novel G protein-coupled receptor genes. Lee DK, et al. Gene, 2001 Sep 5. PMID 11574155
    2. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, et al. Nat Genet, 2009 May. PMID 19377476, Free PMC Article
    3. Identification of G protein-coupled receptor genes from the human genome sequence. Takeda S, et al. FEBS Lett, 2002 Jun 5. PMID 12044878
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 82

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016566.1 RefSeqGene

      Range
      5027..10976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080817.5 → NP_543007.1  probable G-protein coupled receptor 82

      See identical proteins and their annotated locations for NP_543007.1

      Status: VALIDATED

      Source sequence(s)
      AL627402, BC070180
      Consensus CDS
      CCDS14259.1
      UniProtKB/Swiss-Prot
      Q5VT13, Q96P67
      Related
      ENSP00000303549.4, ENST00000302548.5
      Conserved Domains (1) summary
      pfam00001
      Location:32 → 308
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      41724181..41730130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441991.1 → XP_047297947.1  probable G-protein coupled receptor 82 isoform X1

      UniProtKB/Swiss-Prot
      Q5VT13, Q96P67

    2. XM_047441992.1 → XP_047297948.1  probable G-protein coupled receptor 82 isoform X1

      UniProtKB/Swiss-Prot
      Q5VT13, Q96P67

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      41129121..41135070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326835.1 → XP_054182810.1  probable G-protein coupled receptor 82 isoform X1

      UniProtKB/Swiss-Prot
      Q5VT13, Q96P67

    2. XM_054326836.1 → XP_054182811.1  probable G-protein coupled receptor 82 isoform X1

      UniProtKB/Swiss-Prot
      Q5VT13, Q96P67
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96P67.1 GenPept UniProtKB/Swiss-Prot:Q96P67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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