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    CYT1 ubiquinol--cytochrome-c reductase catalytic subunit CYT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CYT1
    Official Full Name
    ubiquinol--cytochrome-c reductase catalytic subunit CYT1
    Primary source
    SGD:S000005591
    Locus tag
    YOR065W
    See related
    AllianceGenome:SGD:S000005591; FungiDB:YOR065W; VEuPathDB:YOR065W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CTC1; YOR29-16
    Summary
    Enables ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CYT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (447439..448368)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L3 Neighboring gene Yng1p Neighboring gene Msa1p Neighboring gene dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of yeast cytochrome c1 is controlled at the transcriptional level by glucose, oxygen and haem. Oechsner U, et al. Mol Gen Genet, 1992 Apr. PMID 1316998
    2. Role of Arg-166 in yeast cytochrome C1. Ahmad Z, et al. J Biol Chem, 2001 May 25. PMID 11279090
    3. Metabolic fate of the increased yeast amino Acid uptake subsequent to catabolite derepression. Hothersall JS, et al. J Amino Acids, 2013. PMID 23431419, Free PMC Article
    4. Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence. Sadler I, et al. EMBO J, 1984 Sep. PMID 6092058, Free PMC Article
    5. Transport of proteins to the mitochondrial intermembrane space: the 'matrix-targeting' and the 'sorting' domains in the cytochrome c1 presequence. van Loon AP, et al. EMBO J, 1987 Aug. PMID 2822392, Free PMC Article

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutational analysis of the Qi-site proton pathway in yeast cytochrome bc1 complex.
      Title: Mutational analysis of the Q(i)-site proton pathway in yeast cytochrome bc(1) complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquinol--cytochrome-c reductase catalytic subunit CYT1
    NP_014708.1
    • Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      447439..448368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183484.1 → NP_014708.1  TPA: ubiquinol--cytochrome-c reductase catalytic subunit CYT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014708.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2C8, P07143
      UniProtKB/TrEMBL
      A0A1L4AA21, A0A5B9RH60, A0A5B9RJN9, A6ZNR7, B3LJB4, B5VRW3, C7GX53, N1NWH9
      Conserved Domains (1) summary
      pfam02167
      Location:76 → 295
      Cytochrom_C1; Cytochrome C1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07143.1

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