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    KSH1 Ksh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1466516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KSH1
    Official Full Name
    Ksh1p
    Primary source
    SGD:S000028698
    Locus tag
    YNL024C-A
    See related
    AllianceGenome:SGD:S000028698; FungiDB:YNL024C-A; VEuPathDB:YNL024C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in intracellular transport and protein secretion. Is active in Golgi apparatus. Orthologous to human TMEM167A (transmembrane protein 167A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KSH1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (586602..586820, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative protein-lysine N-methyltransferase Neighboring gene Fap1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae. He C, et al. J Proteome Res, 2018 Jul 6. PMID 29897761
    2. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
    3. Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Fisk DG, et al. Yeast, 2006 Sep. PMID 17001629, Free PMC Article
    4. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ksh1p
    NP_878158.3
    • Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and cytosol respectively; ortholog of human Kish

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      586602..586820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184619.3 → NP_878158.3  TPA: Ksh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878158.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1F4, Q8TGJ3
      UniProtKB/TrEMBL
      A6ZS51, B3LNP0, C7GWP2, C8ZFK1, G2WM76
      Conserved Domains (1) summary
      pfam06842
      Location:10 → 45
      DUF1242; Protein of unknown function (DUF1242)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TGJ3.1

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