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    AIP1 Aip1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855117, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIP1
    Official Full Name
    Aip1p
    Primary source
    SGD:S000004698
    Locus tag
    YMR092C
    See related
    AllianceGenome:SGD:S000004698; FungiDB:YMR092C; VEuPathDB:YMR092C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables actin binding activity. Involved in actin filament depolymerization; barbed-end actin filament capping; and negative regulation of cytokinesis. Located in actin filament. Is active in actin cortical patch. Used to study hypertrophic cardiomyopathy. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIP1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (451632..453479, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Npl6p Neighboring gene snoRNA-binding rRNA-processing protein UTP15 Neighboring gene Ctf13p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization. Voegtli WC, et al. J Biol Chem, 2003 Sep 5. PMID 12807914
    2. Loss of Aip1 reveals a role in maintaining the actin monomer pool and an in vivo oligomer assembly pathway. Okreglak V, et al. J Cell Biol, 2010 Mar 22. PMID 20231387, Free PMC Article
    3. Aip1p dynamics are altered by the R256H mutation in actin. Pierick AR, et al. J Vis Exp, 2014 Jul 30. PMID 25146730, Free PMC Article
    4. Cooperation of two actin-binding proteins, cofilin and Aip1, in Saccharomyces cerevisiae. Iida K, et al. Genes Cells, 1999 Jan. PMID 10231390
    5. Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo. Lin MC, et al. J Cell Sci, 2010 Apr 15. PMID 20332110, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a new and widely applicable tool to generate conditionally phosphorylated proteins to identify those whose dephosphorylation is required for cytokinesis. This approach identifies Aip1, Ede1 and Inn1 as cytokinetic regulators.
      Title: Identification of Cdk targets that control cytokinesis.
    2. The Aip1 as a crucial factor for shifting the distribution of short actin oligomers toward monomers during disassembly.
      Title: Loss of Aip1 reveals a role in maintaining the actin monomer pool and an in vivo oligomer assembly pathway.
    3. ternary Aip1p/cofilin/actin filament complex model offers insights into how Aip1p may disturb intersubunit contacts within an actin filament
      Title: Biochemical and genetic analyses provide insight into the structural and mechanistic properties of actin filament disassembly by the Aip1p cofilin complex in Saccharomyces cerevisiae.
    4. Cofilin binds AIP1 across the cleft between the two propeller domains, leaving the actin binding sites exposed and flanking the cofilin binding site.
      Title: A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities.
    5. An unanticipated role for Aip1 and cofilin in promoting rapid turnover of yeast actin cables was revealed.
      Title: Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament depolymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament depolymerization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Aip1p
    NP_013810.1
    • Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; mutations in human homolog WDR1 are associated with cardiac hypertrophy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      451632..453479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182592.1 → NP_013810.1  TPA: Aip1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZR5, P46680
      UniProtKB/TrEMBL
      A6ZME9, B5VPL8, C7GL34, G2WKE0
      Conserved Domains (2) summary
      sd00039
      Location:67 → 114
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:58 → 363
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46680.1

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