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    DAT1 Dat1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAT1
    Official Full Name
    Dat1p
    Primary source
    SGD:S000004581
    Locus tag
    YML113W
    See related
    AllianceGenome:SGD:S000004581; FungiDB:YML113W; VEuPathDB:YML113W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DAT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (44045..44791)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Van1p Neighboring gene Taf8p Neighboring gene Ctk3p Neighboring gene ubiquitin-ubiquitin ligase BUL2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A DNA binding protein that recognizes oligo(dA).oligo(dT) tracts. Winter E, et al. EMBO J, 1989 Jun. PMID 2670564, Free PMC Article
    2. Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure. Iyer V, et al. EMBO J, 1995 Jun 1. PMID 7781610, Free PMC Article
    3. A peptide motif that recognizes A.T tracts in DNA. Reardon BJ, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248247, Free PMC Article
    4. DNA binding properties of the Saccharomyces cerevisiae DAT1 gene product. Reardon BJ, et al. Nucleic Acids Res, 1995 Dec 11. PMID 8532535, Free PMC Article
    5. Poly(dA.dT) sequences exist as rigid DNA structures in nucleosome-free yeast promoters in vivo. Suter B, et al. Nucleic Acids Res, 2000 Nov 1. PMID 11058103, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minor groove of adenine-thymine-rich DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dat1p
    NP_013594.1
    • DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      44045..44791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182475.1 → NP_013594.1  TPA: Dat1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0H1, P13483
      UniProtKB/TrEMBL
      C7GV95, G2WJU3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13483.1

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