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    Prrg4 proline rich and Gla domain 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prrg4provided by RGD
    Official Full Name
    proline rich and Gla domain 4provided by RGD
    Primary source
    RGD:1560542
    See related
    EnsemblRapid:ENSRNOG00000022710 AllianceGenome:RGD:1560542
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560542
    Summary
    Predicted to enable WW domain binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be active in extracellular space and plasma membrane. Orthologous to human PRRG4 (proline rich and Gla domain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 149.5), Thymus (RPKM 68.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prrg4 in Genome Data Viewer
    Location:
    3q33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (111669508..111698205, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (91214646..91243347, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (94783866..94808861, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene DEP domain containing 7 Neighboring gene glutamine and serine rich 1 Neighboring gene ribosomal protein L17, pseudogene 17 Neighboring gene coiled-coil domain containing 73

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, et al. PeerJ, 2019. PMID 31687280, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 4
    Names
    proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109203.1 → NP_001102673.1  transmembrane gamma-carboxyglutamic acid protein 4 precursor

      See identical proteins and their annotated locations for NP_001102673.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I5ZRJ1, A6HNV3, D3ZZA9
      Related
      ENSRNOP00000032611.4, ENSRNOT00000038464.6
      Conserved Domains (1) summary
      pfam00594
      Location:57 → 97
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      111669508..111698205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234655.4 → XP_006234717.1  transmembrane gamma-carboxyglutamic acid protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006234717.1

      UniProtKB/TrEMBL
      A0A8I5ZRJ1, A6HNV3, D3ZZA9
      Conserved Domains (1) summary
      pfam00594
      Location:57 → 97
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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