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    Enoph1 enolase-phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67870, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Enoph1provided by MGI
    Official Full Name
    enolase-phosphatase 1provided by MGI
    Primary source
    MGI:MGI:1915120
    See related
    Ensembl:ENSMUSG00000029326 AllianceGenome:MGI:1915120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310057D15Rik
    Summary
    Predicted to enable acireductone synthase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; midbrain; respiratory system; and telencephalon. Orthologous to human ENOPH1 (enolase-phosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 19.1), adrenal adult (RPKM 18.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Enoph1 in Genome Data Viewer
    Location:
    5 E4; 5 48.46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100186887..100216784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100039028..100068925)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene RIKEN cDNA 4930524J08 gene Neighboring gene STARR-seq mESC enhancer starr_13719 Neighboring gene predicted gene, 42127 Neighboring gene STARR-positive B cell enhancer ABC_E2161 Neighboring gene STARR-seq mESC enhancer starr_13720 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene STARR-positive B cell enhancer ABC_E8822 Neighboring gene transmembrane protein 150C, opposite strand Neighboring gene transmembrane protein 150C Neighboring gene predicted gene, 36167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity. Barth A, et al. J Neurochem, 2014 Mar. PMID 24236849
    2. Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP. Yang D, et al. Exp Neurol, 2023 Jul. PMID 37075968
    3. Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways. Ditzen C, et al. Mol Psychiatry, 2010 Jul. PMID 19139748
    4. An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. Kim S, et al. Biol Psychiatry, 2009 Mar 1. PMID 18986647, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP.
      Title: Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP.
    2. Our result suggests a significant role for enoph1 and polyamines in anxiety and depression-related behaviors.
      Title: Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity.
    3. both single-nucleotide polymorphisms were significantly associated with locomotion-independent trait anxiety, further supporting a functional role of EP for this phenotype.
      Title: Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acireductone synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acireductone synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acireductone synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enolase-phosphatase E1
    Names
    2,3-diketo-5-methylthio-1-phosphopentane phosphatase
    MASA homolog
    NP_001156507.1
    NP_080697.2
    XP_006535252.1
    XP_006535253.1
    XP_011247852.1
    XP_030110635.1
    XP_030110636.1
    XP_036021337.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163035.1 → NP_001156507.1  enolase-phosphatase E1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK079062, AK080714, AK167575, BE995909
      Consensus CDS
      CCDS39183.1
      UniProtKB/Swiss-Prot
      Q3TGK8, Q3TXA2, Q3U8Y4, Q8BGB7, Q8VC92, Q9D6U4
      Related
      ENSMUSP00000031268.7, ENSMUST00000031268.8
      Conserved Domains (2) summary
      pfam13419
      Location:13 → 227
      HAD_2; Haloacid dehalogenase-like hydrolase
      cl21460
      Location:10 → 252
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_026421.3 → NP_080697.2  enolase-phosphatase E1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK079062, AK167575, BE995909
      Consensus CDS
      CCDS39183.1
      UniProtKB/Swiss-Prot
      Q3TGK8, Q3TXA2, Q3U8Y4, Q8BGB7, Q8VC92, Q9D6U4
      Related
      ENSMUSP00000129704.2, ENSMUST00000169390.8
      Conserved Domains (2) summary
      pfam13419
      Location:13 → 227
      HAD_2; Haloacid dehalogenase-like hydrolase
      cl21460
      Location:10 → 252
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. NR_027990.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of the first exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), and therefore is not thought to be protein-coding.
      Source sequence(s)
      AK079062, AK167575, BE995909, CX235072

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100186887..100216784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254776.2 → XP_030110636.1  enolase-phosphatase E1 isoform X2

      Conserved Domains (1) summary
      cd01629
      Location:1 → 146
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    2. XM_030254775.2 → XP_030110635.1  enolase-phosphatase E1 isoform X2

      Conserved Domains (1) summary
      cd01629
      Location:1 → 146
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    3. XM_036165444.1 → XP_036021337.1  enolase-phosphatase E1 isoform X2

      Conserved Domains (1) summary
      cd01629
      Location:1 → 146
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    4. XM_011249550.4 → XP_011247852.1  enolase-phosphatase E1 isoform X1

      Conserved Domains (1) summary
      cd01629
      Location:12 → 239
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    5. XM_006535190.3 → XP_006535253.1  enolase-phosphatase E1 isoform X1

      Conserved Domains (1) summary
      cd01629
      Location:12 → 239
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    6. XM_006535189.4 → XP_006535252.1  enolase-phosphatase E1 isoform X1

      Conserved Domains (1) summary
      cd01629
      Location:12 → 239
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGB7.1 GenPept UniProtKB/Swiss-Prot:Q8BGB7

    Gene LinkOut

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