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    Zfp395 zinc finger protein 395 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305972, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp395provided by RGD
    Official Full Name
    zinc finger protein 395provided by RGD
    Primary source
    RGD:1307849
    See related
    EnsemblRapid:ENSRNOG00000014191 AllianceGenome:RGD:1307849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in nucleus. Orthologous to human ZNF395 (zinc finger protein 395). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 77.4), Kidney (RPKM 53.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp395 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43757350..43797513)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39581603..39621911)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48789320..48803025)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene F-box protein 16 Neighboring gene uncharacterized LOC120097019 Neighboring gene prepronociceptin Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene annexin A2, pseudogene1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. Tanaka K, et al. J Biol Chem, 2004 Feb 20. PMID 14625278
    2. Cloning and characterization of a novel MyoD enhancer-binding factor. Yamamoto M, et al. Mech Dev, 2007 Sep-Oct. PMID 17693064, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 395

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107271.2 → NP_001100741.1  zinc finger protein 395

      See identical proteins and their annotated locations for NP_001100741.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6J6, D3ZPR2
      Related
      ENSRNOP00000039094.5, ENSRNOT00000044562.7
      Conserved Domains (1) summary
      pfam15997
      Location:4 → 110
      DUF4772; Domain of unknown function (DUF4772)

    2. NM_001431430.1 → NP_001418359.1  zinc finger protein 395

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6J6, D3ZPR2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      43757350..43797513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093335.2 → XP_038949263.1  zinc finger protein 395 isoform X1

      Conserved Domains (1) summary
      pfam15997
      Location:4 → 110
      DUF4772; Domain of unknown function (DUF4772)

    2. XM_039093334.2 → XP_038949262.1  zinc finger protein 395 isoform X1

      Related
      ENSRNOP00000107819.1, ENSRNOT00000148344.1
      Conserved Domains (1) summary
      pfam15997
      Location:4 → 110
      DUF4772; Domain of unknown function (DUF4772)
    Nucleotide Protein Strain
    Heading Accession and Version

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