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    Dhx32 DEAH-box helicase 32 (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhx32provided by RGD
    Official Full Name
    DEAH-box helicase 32 (putative)provided by RGD
    Primary source
    RGD:1311740
    See related
    EnsemblRapid:ENSRNOG00000018119 AllianceGenome:RGD:1311740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ddx32
    Summary
    Predicted to enable RNA binding activity and helicase activity. Predicted to be located in mitochondrion. Predicted to be part of spliceosomal complex. Orthologous to human DHX32 (DEAH-box helicase 32 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 105.5), Muscle (RPKM 90.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhx32 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (197954503..198013779, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (188524512..188577500, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (205789442..205848727, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene neuromedin U receptor 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 32
    NP_001123511.1
    XP_006230505.1
    XP_038939265.1
    XP_063124006.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130039.1 → NP_001123511.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

      See identical proteins and their annotated locations for NP_001123511.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HX39, A6HX41, D3ZGJ0
      Related
      ENSRNOP00000024655.3, ENSRNOT00000024655.6
      Conserved Domains (4) summary
      smart00847
      Location:472 → 556
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:19 → 687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:86 → 202
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:597 → 704
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      197954503..198013779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267936.1 → XP_063124006.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      UniProtKB/TrEMBL
      A6HX39, A6HX41, D3ZGJ0

    2. XM_006230443.5 → XP_006230505.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      See identical proteins and their annotated locations for XP_006230505.1

      UniProtKB/TrEMBL
      A6HX39, A6HX41, D3ZGJ0
      Conserved Domains (4) summary
      smart00847
      Location:472 → 556
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:19 → 687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:86 → 202
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:597 → 704
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    3. XM_039083337.2 → XP_038939265.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/TrEMBL
      A6HX41
      Conserved Domains (1) summary
      COG1643
      Location:1 → 516
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version

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