EMSLR E2F1 mRNA stabilizing lncRNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: EMSLRprovided by HGNC
Official Full Name: E2F1 mRNA stabilizing lncRNAprovided by HGNC
Primary source: HGNC:HGNC:54408
See related: MIM:618575; AllianceGenome:HGNC:54408
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EMS; BCCE4
Expression: Broad expression in kidney (RPKM 1.1), stomach (RPKM 0.8) and 19 other tissues See more
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Genomic context

Location:: 7q22.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (101308307..101311339)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (102631782..102634814)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (100951588..100954620)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1.
Title: E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1.
Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis.
Title: Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis.
Study reports the lncRNA E2F1 mRNA stabilizing factor (EMS) as a direct c-Myc transcriptional target. EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression. EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression. Furthermore, EMS is able to connect c-Myc to cell cycle control and tumorigenesis via modulating E2F1 mRNA stability.
Title: Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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General gene information

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Other Names

Bladder cancer Cell Cytoplasm-Enriched abundant transcript 4
E2F1 mRNA stabilizing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.