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    KCTD16 potassium channel tetramerization domain containing 16 [ Homo sapiens (human) ]

    Gene ID: 57528, updated on 27-Nov-2024

    Summary

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    Official Symbol
    KCTD16provided by HGNC
    Official Full Name
    potassium channel tetramerization domain containing 16provided by HGNC
    Primary source
    HGNC:HGNC:29244
    See related
    Ensembl:ENSG00000183775 MIM:613423; AllianceGenome:HGNC:29244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cell projection; plasma membrane; and synapse. Predicted to be part of receptor complex. Predicted to be active in postsynaptic membrane and presynaptic membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 4.6), lung (RPKM 0.4) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KCTD16 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (144170873..144485686)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (144702911..145017831)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (143550437..143865249)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 87, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:143543592-143544791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23355 Neighboring gene Yip1 domain family member 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:143677189-143677923 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:143697432-143697944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23357 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:143762205-143763404 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 5 Neighboring gene NANOG hESC enhancer GRCh37_chr5:143867216-143867717 Neighboring gene 60S ribosomal protein L9-like Neighboring gene RN7SK pseudogene 246

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural basis for auxiliary subunit KCTD16 regulation of the GABA(B) receptor. Zuo H, et al. Proc Natl Acad Sci U S A, 2019 Apr 23. PMID 30971491, Free PMC Article
    2. Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein. Yu Y, et al. Neurosci Bull, 2016 Apr. PMID 26960425, Free PMC Article
    3. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Xie T, et al. Neurobiol Aging, 2014 Jul. PMID 24529757
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
    5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1317, MGC138167, DKFZp781A1155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD16
    Names
    potassium channel tetramerisation domain containing 16
    potassium channel tetramerization domain-containing protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370486.1 → NP_001357415.1  BTB/POZ domain-containing protein KCTD16

      Status: VALIDATED

      Source sequence(s)
      AC008383, AC008716
      Consensus CDS
      CCDS34260.1
      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9
      UniProtKB/TrEMBL
      A8K8W2
      Related
      ENSP00000426548.1, ENST00000507359.3
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    2. NM_001370487.1 → NP_001357416.1  BTB/POZ domain-containing protein KCTD16

      Status: VALIDATED

      Source sequence(s)
      AC008383, AC008716
      Consensus CDS
      CCDS34260.1
      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9
      UniProtKB/TrEMBL
      A8K8W2
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    3. NM_020768.4 → NP_065819.1  BTB/POZ domain-containing protein KCTD16

      See identical proteins and their annotated locations for NP_065819.1

      Status: VALIDATED

      Source sequence(s)
      AC008716, AK292477
      Consensus CDS
      CCDS34260.1
      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9
      UniProtKB/TrEMBL
      A8K8W2
      Related
      ENSP00000424151.1, ENST00000512467.6
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      144170873..144485686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417449.1 → XP_047273405.1  BTB/POZ domain-containing protein KCTD16 isoform X2

    2. XM_005268493.3 → XP_005268550.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      See identical proteins and their annotated locations for XP_005268550.1

      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9
      UniProtKB/TrEMBL
      A8K8W2
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    3. XM_011537673.3 → XP_011535975.1  BTB/POZ domain-containing protein KCTD16 isoform X2

      Conserved Domains (2) summary
      smart00225
      Location:27 → 121
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl02518
      Location:27 → 118
      BTB; BTB/POZ domain

    4. XM_047417450.1 → XP_047273406.1  BTB/POZ domain-containing protein KCTD16 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      144702911..145017831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444576.1 → XP_047300532.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9

    2. XM_047444580.1 → XP_047300536.1  BTB/POZ domain-containing protein KCTD16 isoform X2

    3. XM_047444581.1 → XP_047300537.1  BTB/POZ domain-containing protein KCTD16 isoform X2

    4. XM_047444577.1 → XP_047300533.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9

    5. XM_047444575.1 → XP_047300531.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9

    6. XM_047444578.1 → XP_047300534.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/Swiss-Prot
      Q68DU8, Q9P2M9

    7. XM_047444579.1 → XP_047300535.1  BTB/POZ domain-containing protein KCTD16 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68DU8.1 GenPept UniProtKB/Swiss-Prot:Q68DU8

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