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    Lsp1 lymphocyte specific 1 [ Mus musculus (house mouse) ]

    Gene ID: 16985, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lsp1provided by MGI
    Official Full Name
    lymphocyte specific 1provided by MGI
    Primary source
    MGI:MGI:96832
    See related
    Ensembl:ENSMUSG00000018819 AllianceGenome:MGI:96832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; WP34; pp52; Lsp-1
    Summary
    Predicted to enable actin binding activity. Acts upstream of or within cellular response to interleukin-7; chemotaxis; and defense response. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; hair follicle; respiratory system; and thymus. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human LSP1 (lymphocyte specific protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 85.1), bladder adult (RPKM 70.0) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lsp1 in Genome Data Viewer
    Location:
    7 F5; 7 87.93 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142014583..142048605)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142458223..142494868)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20508 Neighboring gene synaptotagmin VIII Neighboring gene troponin I, skeletal, fast 2 Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene proline rich 33 Neighboring gene troponin T3, skeletal, fast Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149724284-149724471 Neighboring gene mitochondrial ribosomal protein L23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. Liu L, et al. J Exp Med, 2005 Feb 7. PMID 15684321, Free PMC Article
    2. A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines. Jongstra J, et al. J Immunol, 1988 Dec 1. PMID 3263441
    3. Protein kinase C phosphorylates p50 LSP1 and induces translocation of p50 LSP1 in T lymphocytes. Matsumoto N, et al. J Biochem, 1995 Jan. PMID 7775393
    4. The LSP1 gene is expressed in cultured normal and transformed mouse macrophages. Jongstra J, et al. Mol Immunol, 1994 Oct. PMID 7935501
    5. Characterization of the 50 kDa protein phosphorylated in concanavalin A-stimulated mouse T cells. Matsumoto N, et al. J Biochem, 1993 May. PMID 8340356

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lymphocyte-Specific Protein 1 Regulates Expression and Stability of Endothelial Nitric Oxide Synthase.
      Title: Lymphocyte-Specific Protein 1 Regulates Expression and Stability of Endothelial Nitric Oxide Synthase.
    2. Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation.
      Title: Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein-Activated Hepatocyte Proliferation.
    3. LSP1-myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration.
      Title: LSP1-myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration.
    4. Regulation of O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 (Lsp1) is a key switch that triggers apoptosis in activated B cells. O-GlcNAcylation at S209 of Lsp1 is a prerequisite for the recruitment of its kinase, PKC-beta1, to induce S243 phosphorylation.
      Title: Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells.
    5. the LSP1-myosin1e bimolecular complex plays a pivotal role in the regulation of actin cytoskeleton remodeling during Fc gamma receptor-driven phagocytosis.
      Title: Crucial role for the LSP1-myosin1e bimolecular complex in the regulation of Fcγ receptor-driven phagocytosis.
    6. the importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported.
      Title: Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis.
    7. Data indicate that in lymphocyte specific 1 protein (LSP1)-deficient mice, PECAM-1 expression was reduced in endothelial cells, but not in neutrophils.
      Title: Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression.
    8. functions as a negative regulator of proliferation and migration in liver
      Title: Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.
    9. TRAF1 and LSP1 cooperate downstream of 4-1BB to activate ERK signaling and down-modulate the levels of Bim leading to enhanced T cell survival.
      Title: Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.
    10. Endothelial LSP1 participates in leukocyte adhesion in vitro, and leukocyte adhesion, through ICAM-1, fosters the activation of endothelial LSP1.
      Title: ICAM-1-mediated leukocyte adhesion is critical for the activation of endothelial LSP1.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte-specific protein 1
    Names
    52 kDa phosphoprotein
    S37 protein
    leukocyte specific protein 1
    lymphocyte-specific antigen WP34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136071.3 → NP_001129543.1  lymphocyte-specific protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001129543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS52450.1
      UniProtKB/Swiss-Prot
      A2A6J5, A2A6J6, P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65
      Related
      ENSMUSP00000018963.5, ENSMUST00000018963.11
      Conserved Domains (1) summary
      pfam02029
      Location:118 → 276
      Caldesmon; Caldesmon

    2. NM_001271508.2 → NP_001258437.1  lymphocyte-specific protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001258437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5'-most exon, initiates translation at an alternate start codon and uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS72073.1
      UniProtKB/TrEMBL
      A2A6J4
      Related
      ENSMUSP00000101586.2, ENSMUST00000105966.2
      Conserved Domains (1) summary
      pfam02029
      Location:116 → 268
      Caldesmon; Caldesmon

    3. NM_001271509.2 → NP_001258438.1  lymphocyte-specific protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Variants 4 and 7 both encode the same isoform (4).
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS72072.1
      UniProtKB/TrEMBL
      A2A6J7
      Related
      ENSMUSP00000101587.2, ENSMUST00000105967.8
      Conserved Domains (1) summary
      pfam02029
      Location:176 → 270
      Caldesmon

    4. NM_001271510.2 → NP_001258439.1  lymphocyte-specific protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001258439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Both variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS52450.1
      UniProtKB/Swiss-Prot
      A2A6J5, A2A6J6, P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65
      Related
      ENSMUSP00000101588.2, ENSMUST00000105968.8
      Conserved Domains (1) summary
      pfam02029
      Location:118 → 276
      Caldesmon; Caldesmon

    5. NM_001271523.1 → NP_001258452.1  lymphocyte-specific protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001258452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate 5'-most exon, uses an alternate splice site in the 5' UTR and initiates translation at a in-frame downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1. Variants 6 and 10-15 all encode the same isoform (5).
      Source sequence(s)
      AK075783, BX631130
      Consensus CDS
      CCDS85469.1
      UniProtKB/TrEMBL
      A0A1B0GRF5
      Related
      ENSMUSP00000147500.2, ENSMUST00000149521.8

    6. NM_001412663.1 → NP_001399592.1  lymphocyte-specific protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      A2A6J7

    7. NM_001412664.1 → NP_001399593.1  lymphocyte-specific protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL603651

    8. NM_001412665.1 → NP_001399594.1  lymphocyte-specific protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL603651

    9. NM_001412666.1 → NP_001399595.1  lymphocyte-specific protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      A0A1B0GRF5

    10. NM_001412667.1 → NP_001399596.1  lymphocyte-specific protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      A0A1B0GRF5

    11. NM_001412668.1 → NP_001399597.1  lymphocyte-specific protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      A0A1B0GRF5

    12. NM_001412669.1 → NP_001399598.1  lymphocyte-specific protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      A0A1B0GRF5

    13. NM_001412670.1 → NP_001399599.1  lymphocyte-specific protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      A0A1B0GRF5

    14. NM_001412671.1 → NP_001399600.1  lymphocyte-specific protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL603651
      UniProtKB/TrEMBL
      A0A1B0GRF5

    15. NM_001412672.1 → NP_001399601.1  lymphocyte-specific protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL603651

    16. NM_001412673.1 → NP_001399602.1  lymphocyte-specific protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL603651

    17. NM_019391.4 → NP_062264.1  lymphocyte-specific protein 1 isoform 2

      See identical proteins and their annotated locations for NP_062264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS40193.1
      UniProtKB/Swiss-Prot
      P19973
      Related
      ENSMUSP00000040637.3, ENSMUST00000038946.9
      Conserved Domains (1) summary
      pfam02029
      Location:116 → 274
      Caldesmon; Caldesmon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      142014583..142048605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152722.1 → XP_036008615.1  lymphocyte-specific protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02029
      Location:169 → 263
      Caldesmon

    2. XM_006508494.3 → XP_006508557.1  lymphocyte-specific protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508557.1

      Conserved Domains (1) summary
      pfam02029
      Location:186 → 280
      Caldesmon

    3. XM_006508495.3 → XP_006508558.1  lymphocyte-specific protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508558.1

      Conserved Domains (1) summary
      pfam02029
      Location:186 → 280
      Caldesmon

    4. XM_006508496.3 → XP_006508559.1  lymphocyte-specific protein 1 isoform X3

      Conserved Domains (1) summary
      pfam02029
      Location:180 → 274
      Caldesmon

    5. XM_030242182.2 → XP_030098042.1  lymphocyte-specific protein 1 isoform X3

      Conserved Domains (1) summary
      pfam02029
      Location:180 → 274
      Caldesmon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19973.2 GenPept UniProtKB/Swiss-Prot:P19973

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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