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    Zbtb3 zinc finger and BTB domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 75291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb3provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 3provided by MGI
    Primary source
    MGI:MGI:1922541
    See related
    Ensembl:ENSMUSG00000071661 AllianceGenome:MGI:1922541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930563M09Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; eye; genitourinary system; heart; and limb mesenchyme. Orthologous to human ZBTB3 (zinc finger and BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 14.8), whole brain E14.5 (RPKM 1.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb3 in Genome Data Viewer
    Location:
    19 A; 19 5.65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8779853..8783035)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8802489..8804853)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein 2 pseudogene Neighboring gene TATA-box binding protein associated factor 6 like Neighboring gene STARR-positive B cell enhancer ABC_E2519 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide G Neighboring gene STARR-positive B cell enhancer ABC_E173 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene STARR-seq mESC enhancer starr_45496 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2 Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene guanine nucleotide binding protein (G protein), gamma 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Floyd JA, et al. Nat Genet, 2003 Nov. PMID 14517553, Free PMC Article
    2. Identification of differentially expressed genes in mouse spermatogenesis. Pang AL, et al. J Androl, 2003 Nov-Dec. PMID 14581517
    3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098237.2 → NP_001091707.1  zinc finger and BTB domain-containing protein 3

      See identical proteins and their annotated locations for NP_001091707.1

      Status: VALIDATED

      Source sequence(s)
      AC129217
      Consensus CDS
      CCDS29548.1
      UniProtKB/Swiss-Prot
      Q3UQP3, Q8BIJ4, Q91X45
      Related
      ENSMUSP00000127746.2, ENSMUST00000172175.3
      Conserved Domains (4) summary
      COG5048
      Location:418 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18323
      Location:1 → 130
      BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
      pfam13465
      Location:433 → 457
      zf-H2C2_2; Zinc-finger double domain

    2. NM_133759.4 → NP_598520.1  zinc finger and BTB domain-containing protein 3

      See identical proteins and their annotated locations for NP_598520.1

      Status: VALIDATED

      Source sequence(s)
      AC129217
      Consensus CDS
      CCDS29548.1
      UniProtKB/Swiss-Prot
      Q3UQP3, Q8BIJ4, Q91X45
      Conserved Domains (4) summary
      COG5048
      Location:418 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18323
      Location:1 → 130
      BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
      pfam13465
      Location:433 → 457
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8779853..8783035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527420.5 → XP_006527483.1  zinc finger and BTB domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      cd18323
      Location:1 → 130
      BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)

    2. XM_006527419.3 → XP_006527482.1  zinc finger and BTB domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006527482.1

      UniProtKB/Swiss-Prot
      Q3UQP3, Q8BIJ4, Q91X45
      Conserved Domains (4) summary
      COG5048
      Location:418 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18323
      Location:1 → 130
      BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
      pfam13465
      Location:433 → 457
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91X45.3 GenPept UniProtKB/Swiss-Prot:Q91X45

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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