U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Csnk1d casein kinase 1, delta [ Mus musculus (house mouse) ]

    Gene ID: 104318, updated on 4-Jan-2025

    Summary

    Official Symbol
    Csnk1dprovided by MGI
    Official Full Name
    casein kinase 1, deltaprovided by MGI
    Primary source
    MGI:MGI:1355272
    See related
    Ensembl:ENSMUSG00000025162 AllianceGenome:MGI:1355272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200006A05Rik; D930010H05Rik
    Summary
    This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 50.8), whole brain E14.5 (RPKM 50.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Csnk1d in Genome Data Viewer
    Location:
    11 E2; 11 84.75 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120848535..120882180, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120957709..120991350, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304 Neighboring gene STARR-seq mESC enhancer starr_31376 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 3 Neighboring gene STARR-positive B cell enhancer ABC_E8477 Neighboring gene predicted gene, 53204 Neighboring gene predicted gene, 30062

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables kinase activity  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    enables tau-protein kinase activity  
    enables tau-protein kinase activity  
    Items 1 - 25 of 35
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization  
    involved_in Wnt signaling pathway  
    involved_in chromatin remodeling  
    involved_in circadian regulation of gene expression PubMed 
    involved_in endocytosis  
    acts_upstream_of_or_within microtubule nucleation  
    involved_in midbrain dopaminergic neuron differentiation PubMed 
    involved_in non-motile cilium assembly  
    acts_upstream_of_or_within non-motile cilium assembly PubMed 
    acts_upstream_of_or_within non-motile cilium assembly  
    involved_in positive regulation of Wnt signaling pathway PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of non-canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of protein phosphorylation  
    acts_upstream_of_or_within protein localization to Golgi apparatus  
    acts_upstream_of_or_within protein localization to centrosome  
    acts_upstream_of_or_within protein localization to cilium  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm PubMed 
    involved_in signal transduction  
    involved_in spindle assembly  
    involved_in spindle assembly  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in spindle  
    located_in spindle  
    is_active_in spindle microtubule  
    located_in spindle microtubule  

    General protein information

    Preferred Names
    casein kinase I isoform delta; casein kinase I
    Names
    CKI-delta
    CKId
    tau-protein kinase CSNK1D
    NP_082150.1
    NP_620690.1
    XP_011246964.1
    XP_011246965.1
    XP_036012094.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027874.3NP_082150.1  casein kinase I isoform delta isoform 2

      See identical proteins and their annotated locations for NP_082150.1

      Status: VALIDATED

      Source sequence(s)
      AL662887, AL662901
      Consensus CDS
      CCDS25763.1
      UniProtKB/TrEMBL
      Q3UBT6
      Related
      ENSMUSP00000070721.8, ENSMUST00000070575.14
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    2. NM_139059.3NP_620690.1  casein kinase I isoform delta isoform 1

      See identical proteins and their annotated locations for NP_620690.1

      Status: VALIDATED

      Source sequence(s)
      AL662887, AL662901
      Consensus CDS
      CCDS25762.1
      UniProtKB/Swiss-Prot
      Q3TZK2, Q99KK4, Q9DC28
      Related
      ENSMUSP00000018274.4, ENSMUST00000018274.10
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120848535..120882180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248663.4XP_011246965.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011246965.1

      UniProtKB/TrEMBL
      Q3USK2
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    2. XM_011248662.3XP_011246964.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011246964.1

      UniProtKB/TrEMBL
      Q3USK2
      Related
      ENSMUSP00000158953.2, ENSMUST00000239115.2
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    3. XM_036156201.1XP_036012094.1  casein kinase I isoform X2

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    External link. Please review our privacy policy.