Tbc1d31 TBC1 domain family, member 31 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbc1d31provided by MGI
Official Full Name: TBC1 domain family, member 31provided by MGI
Primary source: MGI:MGI:2684931
See related: Ensembl:ENSMUSG00000022364 AllianceGenome:MGI:2684931
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4B3; Gm85; Wdr67; D330013L20Rik
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in cilium assembly. Predicted to be located in centriolar satellite. Predicted to be active in ciliary basal body. Orthologous to human TBC1D31 (TBC1 domain family member 31). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 7.4), CNS E11.5 (RPKM 4.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 24.08 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (57775081..57833464)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (57911685..57970068)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TBC1 domain family member 31

Names: WD repeat domain 67; WD repeat-containing protein 67; protein 4-B-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081396.2 → NP_001074865.2 TBC1 domain family member 31 isoform 1

See identical proteins and their annotated locations for NP_001074865.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

AC154874, BC050039, BC066830

Consensus CDS

CCDS37077.2

UniProtKB/Swiss-Prot

Q3TBW4, Q3U4F6, Q5KSA3, Q6NXY1, Q810J7, Q8C3Y2

Related

ENSMUSP00000022992.7, ENSMUST00000022992.13

Conserved Domains (6) summary

COG2319
Location:34 → 346

WD40; WD40 repeat [General function prediction only]

pfam15346
Location:766 → 895

ARGLU; Arginine and glutamate-rich 1

sd00039
Location:43 → 81

7WD40; WD40 repeat [structural motif]

cl02495
Location:461 → 619

RabGAP-TBC; Rab-GTPase-TBC domain

cl02567
Location:39 → 334

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl23750
Location:713 → 834

vATP-synt_E; ATP synthase (E/31 kDa) subunit
NM_001167679.1 → NP_001161151.1 TBC1 domain family member 31 isoform 2

See identical proteins and their annotated locations for NP_001161151.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

AC154874

UniProtKB/TrEMBL

Q3UR49

Related

ENSMUST00000110175.9

Conserved Domains (5) summary

COG2319
Location:34 → 346

WD40; WD40 repeat [General function prediction only]

sd00039
Location:43 → 81

7WD40; WD40 repeat [structural motif]

cl02495
Location:461 → 619

RabGAP-TBC; Rab-GTPase-TBC domain

cl02567
Location:39 → 334

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl23750
Location:713 → 834

vATP-synt_E; ATP synthase (E/31 kDa) subunit
NM_001356310.1 → NP_001343239.1 TBC1 domain family member 31 isoform 3

Status: VALIDATED

Source sequence(s)

AC154874

Conserved Domains (4) summary

sd00039
Location:45 → 80

7WD40; WD40 repeat [structural motif]

cl02495
Location:343 → 520

RabGAP-TBC; Rab-GTPase-TBC domain

cl25539
Location:30 → 249

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl25545
Location:599 → 821

V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

57775081..57833464

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520700.3 → XP_006520763.1 TBC1 domain family member 31 isoform X2

See identical proteins and their annotated locations for XP_006520763.1

Conserved Domains (4) summary

sd00039
Location:45 → 80

7WD40; WD40 repeat [structural motif]

pfam17380
Location:599 → 921

DUF5401; Family of unknown function (DUF5401)

cl02495
Location:343 → 534

RabGAP-TBC; Rab-GTPase-TBC domain

cl29593
Location:30 → 249

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006520698.3 → XP_006520761.1 TBC1 domain family member 31 isoform X1

Conserved Domains (4) summary

sd00039
Location:43 → 81

7WD40; WD40 repeat [structural motif]

pfam17380
Location:684 → 1006

DUF5401; Family of unknown function (DUF5401)

cl02495
Location:428 → 619

RabGAP-TBC; Rab-GTPase-TBC domain

cl29593
Location:39 → 334

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006520699.3 → XP_006520762.1 TBC1 domain family member 31 isoform X2

See identical proteins and their annotated locations for XP_006520762.1

Conserved Domains (4) summary

sd00039
Location:45 → 80

7WD40; WD40 repeat [structural motif]

pfam17380
Location:599 → 921

DUF5401; Family of unknown function (DUF5401)

cl02495
Location:343 → 534

RabGAP-TBC; Rab-GTPase-TBC domain

cl29593
Location:30 → 249

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030248441.1 → XP_030104301.1 TBC1 domain family member 31 isoform X3

Conserved Domains (4) summary

sd00039
Location:9 → 44

7WD40; WD40 repeat [structural motif]

pfam17380
Location:563 → 874

DUF5401; Family of unknown function (DUF5401)

cl02495
Location:307 → 498

RabGAP-TBC; Rab-GTPase-TBC domain

cl29593
Location:1 → 213

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036159297.1 → XP_036015190.1 TBC1 domain family member 31 isoform X4

Conserved Domains (4) summary

sd00039
Location:9 → 44

7WD40; WD40 repeat [structural motif]

pfam17380
Location:563 → 820

DUF5401; Family of unknown function (DUF5401)

cl02495
Location:307 → 498

RabGAP-TBC; Rab-GTPase-TBC domain

cl29593
Location:1 → 213

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006520702.3 → XP_006520765.1 TBC1 domain family member 31 isoform X3

See identical proteins and their annotated locations for XP_006520765.1

Conserved Domains (4) summary

sd00039
Location:9 → 44

7WD40; WD40 repeat [structural motif]

pfam17380
Location:563 → 874

DUF5401; Family of unknown function (DUF5401)

cl02495
Location:307 → 498

RabGAP-TBC; Rab-GTPase-TBC domain

cl29593
Location:1 → 213

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006520703.3 → XP_006520766.1 TBC1 domain family member 31 isoform X3

See identical proteins and their annotated locations for XP_006520766.1

Conserved Domains (4) summary

sd00039
Location:9 → 44

7WD40; WD40 repeat [structural motif]

pfam17380
Location:563 → 874

DUF5401; Family of unknown function (DUF5401)

cl02495
Location:307 → 498

RabGAP-TBC; Rab-GTPase-TBC domain

cl29593
Location:1 → 213

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_199300.1: Suppressed sequence

Description

NM_199300.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.