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    TKL2 transketolase TKL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TKL2
    Official Full Name
    transketolase TKL2
    Primary source
    SGD:S000000321
    Locus tag
    YBR117C
    See related
    AllianceGenome:SGD:S000000321; FungiDB:YBR117C; VEuPathDB:YBR117C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transketolase activity. Involved in pentose-phosphate shunt. Located in cytoplasm and nucleus. Orthologous to human TKT (transketolase); TKTL1 (transketolase like 1); and TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TKL2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (474392..476437, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA repair protein RAD16 Neighboring gene L-aminoadipate-semialdehyde dehydrogenase Neighboring gene translation elongation factor EF-1 alpha Neighboring gene Mud1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism. Blank HM, et al. Mol Biol Cell, 2020 May 1. PMID 32129706, Free PMC Article
    2. Analysis of a transketolase gene from Kluyveromyces lactis reveals that the yeast enzymes are more related to transketolases of prokaryotic origins than to those of higher eukaryotes. Jacoby JJ, et al. Curr Genet, 1997 Jan. PMID 9000376
    3. Kinetics of reconstruction of holo-transketolase. Kochetov GA, et al. FEBS Lett, 1975 May 1. PMID 1095414
    4. Two methods for determination of transketolase activity. Sevostyanova IA, et al. Biochemistry (Mosc), 2006 May. PMID 16732737
    5. Theoretical model of interactions between ligand-binding sites in a dimeric protein and its application for the analysis of thiamine diphosphate binding to yeast transketolase. Ospanov R, et al. Biophys Chem, 2006 Nov 20. PMID 16837121

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
      Title: Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
    2. In the presence of Ca2+, the active sites of TK1 and TK2 exhibit negative cooperativity in binding both xylulose-5-phosphate and ribose-5-phosphate and positive cooperativity in the catalytic transformation of the substrates.
      Title: Cooperative binding of substrates to transketolase from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transketolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transketolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pentose-phosphate shunt IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    transketolase TKL2
    NP_009675.3
    • Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      474392..476437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178465.3 → NP_009675.3  TPA: transketolase TKL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009675.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQB5, P33315
      UniProtKB/TrEMBL
      A6ZL62, B3LN38, B5VE78, C7GUL3, D3UEK9, G2W9C2, N1PAT1
      Conserved Domains (1) summary
      TIGR00232
      Location:9 → 665
      tktlase_bact; transketolase, bacterial and yeast
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33315.1

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