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    ERG25 methylsterol monooxygenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERG25
    Official Full Name
    methylsterol monooxygenase
    Primary source
    SGD:S000003292
    Locus tag
    YGR060W
    See related
    AllianceGenome:SGD:S000003292; FungiDB:YGR060W; VEuPathDB:YGR060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables C-4 methylsterol oxidase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and plasma membrane. Is active in endoplasmic reticulum. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERG25 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (610564..611493)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene septin SPR3 Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene membrane insertase COX18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional identification of C-4 methyl sterol oxidase genes from the penicillin-producing fungus Penicillium chrysogenum. Wang FQ, et al. FEMS Microbiol Lett, 2008 Oct. PMID 18707625
    2. Inhibition of sterol biosynthesis reduces tombusvirus replication in yeast and plants. Sharma M, et al. J Virol, 2010 Mar. PMID 20015981, Free PMC Article
    3. Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis. Darnet S, et al. Biochim Biophys Acta, 2003 Jul 21. PMID 12880870
    4. Isolation of temperature-sensitive Saccharomyces cerevisiae with a mutation in erg25 for C-4 sterol methyl oxidase. Nose H, et al. J Antibiot (Tokyo), 2002 Nov. PMID 12546417
    5. Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. Li L, et al. J Biol Chem, 1996 Jul 12. PMID 8663358

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.
      Title: The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-4 methylsterol oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables C-4 methylsterol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-4 methylsterol oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methylsterol monooxygenase
    NP_011574.3
    • C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      610564..611493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181189.3 → NP_011574.3  TPA: methylsterol monooxygenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011574.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUJ5, E9P8T3, P53045, Q45U26
      UniProtKB/TrEMBL
      A6ZV45, B3LIG3, B5VJ10, C7GXP3, C8Z8V4, G2WEE7, N1P254
      Conserved Domains (1) summary
      COG3000
      Location:35 → 307
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53045.1

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