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    uba-1 E1 ubiquitin-activating enzyme [ Caenorhabditis elegans ]

    Gene ID: 177855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uba-1
    Official Full Name
    E1 ubiquitin-activating enzyme
    Primary source
    WormBase:WBGene00006699
    Locus tag
    CELE_C47E12.5
    See related
    AllianceGenome:WB:WBGene00006699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin activating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and programmed cell death involved in cell development. Located in nucleus. Is expressed in several structures, including anterior hypodermis; germ line; head muscle; midbody; and neurons. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See uba-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (9989673..9994945, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inorganic pyrophosphatase 1 Neighboring gene alpha-1,2-Mannosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A catechin-enriched green tea extract prevents glucose-induced survival reduction in Caenorhabditis elegans through sir-2.1 and uba-1 dependent hormesis. Deusing DJ, et al. Fitoterapia, 2015 Apr. PMID 25771124
    2. F-box protein FBXB-65 regulates anterograde transport of the kinesin-3 motor UNC-104 through a PTM near its cargo-binding PH domain. Sabharwal V, et al. J Cell Sci, 2024 Apr 1. PMID 38477340,
    3. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Walker AK, et al. Dev Biol, 2007 Apr 1. PMID 17291483, Free PMC Article
    4. E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development. Kulkarni M, et al. PLoS Genet, 2008 Jul 18. PMID 18636104, Free PMC Article
    5. Regulation of mechanosensation in C. elegans through ubiquitination of the MEC-4 mechanotransduction channel. Chen X, et al. J Neurosci, 2015 Feb 4. PMID 25653375, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. uba-1 plays multiple roles throughout C. elegans development.
      Title: E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E1 ubiquitin-activating enzyme
    NP_001033404.1
    • Confirmed by transcript evidence
    NP_001367213.1
    • Confirmed by transcript evidence
    NP_001379450.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9989673..9994945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038315.9 → NP_001033404.1  E1 ubiquitin-activating enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27481
      Conserved Domains (1) summary
      TIGR01408
      Location:103 → 1111
      Ube1; ubiquitin-activating enzyme E1

    2. NM_001392377.1 → NP_001379450.1  E1 ubiquitin-activating enzyme [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3S1J5
      Conserved Domains (1) summary
      TIGR01408
      Location:18 → 1026
      Ube1; ubiquitin-activating enzyme E1

    3. NM_001380424.1 → NP_001367213.1  E1 ubiquitin-activating enzyme [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P636
      Conserved Domains (1) summary
      TIGR01408
      Location:102 → 1110
      Ube1; ubiquitin-activating enzyme E1
    Nucleotide Protein
    Heading Accession and Version

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