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    ddx-35 putative ATP-dependent RNA helicase DHX35 homolog [ Caenorhabditis elegans ]

    Gene ID: 175308, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx-35
    Official Full Name
    putative ATP-dependent RNA helicase DHX35 homolog
    Primary source
    WormBase:WBGene00022056
    Locus tag
    CELE_Y67D2.6
    See related
    AllianceGenome:WB:WBGene00022056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and helicase activity. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX35 (DEAH-box helicase 35). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddx-35 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (1544948..1554447, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 9-like protein Neighboring gene Iron-binding zinc finger CDGSH type domain-containing protein Neighboring gene ncRNA Neighboring gene Early ELOngation arrest Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in reproductive process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase DHX35 homolog
    NP_497420.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1544948..1554447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065019.5 → NP_497420.1  putative ATP-dependent RNA helicase DHX35 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BKQ8
      Conserved Domains (5) summary
      smart00847
      Location:484 → 568
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:70 → 702
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:96 → 233
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:284 → 416
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:602 → 704
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BKQ8.1

    Gene LinkOut

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