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    eef-1B.2 putative elongation factor 1-beta/1-delta 2 [ Caenorhabditis elegans ]

    Gene ID: 178419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eef-1B.2
    Official Full Name
    putative elongation factor 1-beta/1-delta 2
    Primary source
    WormBase:WBGene00012768
    Locus tag
    CELE_Y41E3.10
    See related
    AllianceGenome:WB:WBGene00012768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to several human genes including EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eef-1B.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (15037331..15039551)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FANCD2 Neighboring gene Glycine Rich Secreted Protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene B30.2/SPRY domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans. Son HG, et al. Genes Dev, 2018 Dec 1. PMID 30478249, Free PMC Article
    2. Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. Zheleva A, et al. PLoS Genet, 2019 Sep. PMID 31525188, Free PMC Article
    3. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
    4. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    5. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (uridine-N3-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA base methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative elongation factor 1-beta/1-delta 2
    NP_001122811.1
    • Confirmed by transcript evidence
    NP_502816.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      15037331..15039551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129339.2 → NP_001122811.1  putative elongation factor 1-beta/1-delta 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U2H9
      Conserved Domains (2) summary
      pfam10354
      Location:122 → 294
      DUF2431; Domain of unknown function (DUF2431)
      cl00518
      Location:388 → 439
      Asp_Glu_race; Asp/Glu/Hydantoin racemase

    2. NM_070415.6 → NP_502816.2  putative elongation factor 1-beta/1-delta 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502816.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3RMU4, H9G359, H9G360, Q9U2H9
      Conserved Domains (1) summary
      pfam00736
      Location:179 → 263
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2H9.4

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