U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hgap-2 Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein;Rap-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3564922, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hgap-2
    Official Full Name
    Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein;Rap-GAP domain-containing protein
    Primary source
    WormBase:WBGene00008430
    Locus tag
    CELE_D2085.5
    See related
    AllianceGenome:WB:WBGene00008430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in determination of adult lifespan. Is expressed in pharyngeal gland cell and pharyngeal muscle cell. Orthologous to human RALGAPB (Ral GTPase activating protein non-catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See hgap-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    30
    Sequence:
    Chromosome: II; NC_003280.10 (8669133..8684924, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Translation initiation factor eIF2B subunit epsilon Neighboring gene Ubiquitin-like-conjugating enzyme ATG10 Neighboring gene PIGA GPI anchor biosynthesis domain-containing protein Neighboring gene E3 ubiquitin-protein ligase etc-1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RAL-1 signaling regulates lipid composition in C. elegans. Wu Y, et al. MicroPubl Biol, 2024. PMID 38454952, Free PMC Article
    2. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Martin TD, et al. Mol Cell, 2014 Jan 23. PMID 24389102, Free PMC Article
    3. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ral protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein;Rap-GAP domain-containing protein
    NP_001022054.1
    • Partially confirmed by transcript evidence
    NP_001254166.1
    • Partially confirmed by transcript evidence
    NP_001254167.1
    • Partially confirmed by transcript evidence
    NP_001254169.1
    • Partially confirmed by transcript evidence
    NP_001254170.1
    • Confirmed by transcript evidence
    NP_001254171.1
    • Partially confirmed by transcript evidence
    NP_001254172.1
    • Partially confirmed by transcript evidence
    NP_001254173.1
    • Confirmed by transcript evidence
    NP_001334204.1
    • Partially confirmed by transcript evidence
    NP_001334205.1
    • Confirmed by transcript evidence
    NP_001368613.1
    • Confirmed by transcript evidence
    NP_001370880.1
    • Confirmed by transcript evidence
    NP_001379401.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8669133..8684924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267237.4 → NP_001254166.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Q2
      Conserved Domains (1) summary
      pfam02145
      Location:1077 → 1136
      Rap_GAP; Rap/ran-GAP

    2. NM_001026883.4 → NP_001022054.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECF5
      Conserved Domains (1) summary
      pfam02145
      Location:946 → 1005
      Rap_GAP; Rap/ran-GAP

    3. NM_001383906.1 → NP_001370880.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Q7

    4. NM_001393138.1 → NP_001379401.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG57

    5. NM_001381532.1 → NP_001368613.1  Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I6CM66

    6. NM_001347287.3 → NP_001334204.1  Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I6CM55
      Conserved Domains (1) summary
      pfam02145
      Location:1640 → 1699
      Rap_GAP; Rap/ran-GAP

    7. NM_001347288.3 → NP_001334205.1  Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I6CM80
      Conserved Domains (1) summary
      pfam02145
      Location:1583 → 1642
      Rap_GAP; Rap/ran-GAP

    8. NM_001267244.3 → NP_001254173.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Q5
      Conserved Domains (1) summary
      pfam02145
      Location:953 → 1012
      Rap_GAP; Rap/ran-GAP

    9. NM_001267241.3 → NP_001254170.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Q6
      Conserved Domains (1) summary
      pfam02145
      Location:1044 → 1103
      Rap_GAP; Rap/ran-GAP

    10. NM_001267242.3 → NP_001254171.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGJ0
      Conserved Domains (1) summary
      pfam02145
      Location:986 → 1045
      Rap_GAP; Rap/ran-GAP

    11. NM_001267240.3 → NP_001254169.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Q8
      Conserved Domains (1) summary
      pfam02145
      Location:1037 → 1096
      Rap_GAP; Rap/ran-GAP

    12. NM_001267243.3 → NP_001254172.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Q4
      Conserved Domains (1) summary
      pfam02145
      Location:927 → 986
      Rap_GAP; Rap/ran-GAP

    13. NM_001267238.3 → NP_001254167.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2Q3
      Conserved Domains (1) summary
      pfam02145
      Location:1018 → 1077
      Rap_GAP; Rap/ran-GAP
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools