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    cct-2 T-complex protein 1 subunit beta [ Caenorhabditis elegans ]

    Gene ID: 174421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cct-2
    Official Full Name
    T-complex protein 1 subunit beta
    Primary source
    WormBase:WBGene00000378
    Locus tag
    CELE_T21B10.7
    See related
    AllianceGenome:WB:WBGene00000378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytosol. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including alimentary muscle; body wall musculature; hypodermis; tail; and touch receptor neurons. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cct-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8927741..8929815)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Expressed conserved protein Neighboring gene Glycine-rich protein Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein mL50 Neighboring gene Enolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shigella flexneri infection in Caenorhabditis elegans: cytopathological examination and identification of host responses. George DT, et al. PLoS One, 2014. PMID 25187942, Free PMC Article
    2. Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans. Leroux MR, et al. DNA Cell Biol, 1995 Nov. PMID 7576182
    3. Postembryonic RNAi in Heterorhabditis bacteriophora: a nematode insect parasite and host for insect pathogenic symbionts. Ciche TA, et al. BMC Dev Biol, 2007 Sep 5. PMID 17803822, Free PMC Article
    4. Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells. Saegusa K, et al. Mol Biol Cell, 2014 Oct 15. PMID 25143409, Free PMC Article
    5. An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes. Maheshwari R, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849797, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chaperonin-containing T-complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 1 subunit beta
    NP_741031.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8927741..8929815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171985.8 → NP_741031.1  T-complex protein 1 subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47207, Q22628
      Conserved Domains (2) summary
      cd03336
      Location:6 → 520
      TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02341
      Location:5 → 522
      chap_CCT_beta; T-complex protein 1, beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47207.2

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