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    nepr-1 Nuclear envelope phosphatase-regulatory subunit 1 homolog;Transmembrane protein 188 [ Caenorhabditis elegans ]

    Gene ID: 172625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nepr-1
    Official Full Name
    Nuclear envelope phosphatase-regulatory subunit 1 homolog;Transmembrane protein 188
    Primary source
    WormBase:WBGene00011828
    Locus tag
    CELE_T19A6.3
    See related
    AllianceGenome:WB:WBGene00011828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of nuclear division. Predicted to be located in nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Predicted to be active in cytoplasm. Orthologous to human CNEP1R1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nepr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (8398918..8400504)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PQ-loop repeat-containing protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nucleolar GTP-binding protein 2 Neighboring gene Transmembrane protein 144 Neighboring gene Suppressor protein SRP40-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. Han S, et al. J Biol Chem, 2012 Jan 27. PMID 22134922, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Nem1-Spo7 phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Nem1-Spo7 phosphatase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Nem1-Spo7 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear envelope phosphatase-regulatory subunit 1 homolog;Transmembrane protein 188
    NP_001122519.1
    • Partially confirmed by transcript evidence
    NP_492277.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8398918..8400504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129047.6 → NP_001122519.1  Transmembrane protein 188 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5PEW7
      Conserved Domains (1) summary
      pfam09771
      Location:14 → 137
      Tmemb_18A; Transmembrane protein 188

    2. NM_059876.6 → NP_492277.1  Nuclear envelope phosphatase-regulatory subunit 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492277.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XXN3
      Conserved Domains (1) summary
      pfam09771
      Location:14 → 135
      Tmemb_18A; Transmembrane protein 188
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXN3.2

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