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    cosa-1 Cyclin N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cosa-1
    Official Full Name
    Cyclin N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00022172
    Locus tag
    CELE_Y71H2AM.7
    See related
    AllianceGenome:WB:WBGene00022172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in reciprocal meiotic recombination. Located in site of double-strand break. Orthologous to human CNTD1 (cyclin N-terminal domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cosa-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (2726116..2731670)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 132 homolog Neighboring gene tRNA-Pro Neighboring gene Peptidase M20 dimerization domain-containing protein Neighboring gene Ras-related protein Rab-18 Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene L-Fucosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual tagging of GFP and Degron on endogenous COSA-1 in Caenorhabditis elegans as a crossover investigation tool. Odiba AS, et al. MicroPubl Biol, 2024. PMID 38304162, Free PMC Article
    2. Epitope tag-specific differences in the detection of COSA-1 marked crossover sites in C. elegans spermatocytes. Cahoon CK, et al. MicroPubl Biol, 2023. PMID 36660421, Free PMC Article
    3. An endogenous mCherry-tagged COSA-1 as a crossover investigation tool in Caenorhabditis elegans. Ezechukwu CS, et al. MicroPubl Biol, 2022. PMID 36060030, Free PMC Article
    4. Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis. Pattabiraman D, et al. PLoS Genet, 2017 Mar. PMID 28339470, Free PMC Article
    5. Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1. Girard C, et al. MicroPubl Biol, 2021. PMID 34458691, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cyclin N-terminal domain-containing protein
    NP_497607.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2726116..2731670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065206.6 → NP_497607.3  Cyclin N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497607.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL45
    Nucleotide Protein
    Heading Accession and Version

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