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    laat-1 Lysosomal amino acid transporter 1 [ Caenorhabditis elegans ]

    Gene ID: 3565323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    laat-1
    Official Full Name
    Lysosomal amino acid transporter 1
    Primary source
    WormBase:WBGene00021546
    Locus tag
    CELE_Y43H11AL.2
    See related
    AllianceGenome:WB:WBGene00021546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables L-arginine transmembrane transporter activity and L-lysine transmembrane transporter activity. Involved in basic amino acid transport; intracellular amino acid homeostasis; and positive regulation of autophagy. Located in lysosomal membrane. Used to study lysosomal storage disease. Orthologous to several human genes including SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See laat-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (233139..237821, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UBX domain-containing protein 3 Neighboring gene ncRNA Neighboring gene ING domain-containing protein;PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nipped-B-like protein scc-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. Wu Y, et al. EMBO Rep, 2014 Sep. PMID 25124690, Free PMC Article
    2. PtdIns(4,5)P₂ and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. Cheng S, et al. J Cell Biol, 2015 Aug 3. PMID 26240185, Free PMC Article
    3. Visualizing Phagocytic Cargo In Vivo from Engulfment to Resolution in Caenorhabditis elegans. Fazeli G, et al. Methods Mol Biol, 2023. PMID 37365478
    4. Phosphatidylcholine deficiency increases ferroptosis susceptibility in the Caenorhabditis elegans germline. Zhu J, et al. J Genet Genomics, 2023 May. PMID 36933794
    5. Asymmetric organelle positioning during epithelial polarization of C. elegans intestinal cells. Brandt JN, et al. Dev Biol, 2022 Jan. PMID 34597675, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-lysine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables basic amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular amino acid homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lysosomal amino acid transporter 1
    NP_001300603.1
    • Confirmed by transcript evidence
    NP_493686.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      233139..237821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061285.7 → NP_493686.2  Lysosomal amino acid transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493686.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XZ6
      Conserved Domains (1) summary
      pfam04193
      Location:42 → 97
      PQ-loop; PQ loop repeat

    2. NM_001313674.3 → NP_001300603.1  Lysosomal amino acid transporter 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARR4
      Conserved Domains (1) summary
      pfam04193
      Location:113 → 171
      PQ-loop; PQ loop repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XZ6.2

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