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    amx-2 monoamine oxidase [ Caenorhabditis elegans ]

    Gene ID: 173146, updated on 9-Dec-2024

    Summary

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    Official Symbol
    amx-2
    Official Full Name
    monoamine oxidase
    Primary source
    WormBase:WBGene00000138
    Locus tag
    CELE_B0019.1
    See related
    AllianceGenome:WB:WBGene00000138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be located in mitochondrial outer membrane. Is expressed in several structures, including HSN; anus; pharyngeal muscle cell; rectal epithelium; and vulva. Human ortholog(s) of this gene implicated in Brunner Syndrome; alcohol use disorder; autism spectrum disorder; neurodegenerative disease (multiple); and panic disorder. Orthologous to several human genes including MAOA (monoamine oxidase A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See amx-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (12759587..12764960, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene BTB domain-containing protein Neighboring gene SPK domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA. Schmid T, et al. PLoS Genet, 2015 May. PMID 25978500, Free PMC Article
    2. Ras/MAPK Modifier Loci Revealed by eQTL in Caenorhabditis elegans. Sterken MG, et al. G3 (Bethesda), 2017 Sep 7. PMID 28751501, Free PMC Article
    3. G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. Wang J, et al. J Biol Chem, 2017 Apr 7. PMID 28213524, Free PMC Article
    4. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate that GRK-2 modulates 5-HT metabolism by regulating AMX-2 function and that 5-HIAA may function in the SER-1 signaling pathway.
      Title: G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    monoamine oxidase
    NP_001369790.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12759587..12764960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383739.2 → NP_001369790.1  monoamine oxidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXU5
      Conserved Domains (1) summary
      pfam01593
      Location:55 → 472
      Amino_oxidase; Flavin containing amine oxidoreductase
    Nucleotide Protein
    Heading Accession and Version

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