U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    smgl-1 Neuroblastoma-amplified sequence [ Caenorhabditis elegans ]

    Gene ID: 172561, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    smgl-1
    Official Full Name
    Neuroblastoma-amplified sequence
    Primary source
    WormBase:WBGene00008990
    Locus tag
    CELE_F20G4.1
    See related
    AllianceGenome:WB:WBGene00008990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNARE binding activity. Involved in nuclear-transcribed mRNA catabolic process. Predicted to be part of Dsl1/NZR complex. Is expressed in hermaphrodite gonad; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human NBAS (NBAS subunit of NRZ tethering complex). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See smgl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (7918447..7926338, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor unc-55 Neighboring gene Uncharacterized protein Neighboring gene Activin_recp domain-containing protein;Serine/threonine-protein kinase kinx Neighboring gene Non-specific serine/threonine protein kinase Neighboring gene Myosin-11 Neighboring gene UBR-type domain-containing protein Neighboring gene Globin-like protein 26

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression and Purification of SMGL-1. Wang M, et al. Stud Health Technol Inform, 2023 Nov 23. PMID 38007727
    2. Coordination of RAB-8 and RAB-11 during unconventional protein secretion. Li X, et al. J Cell Biol, 2024 Feb 5. PMID 38019180, Free PMC Article
    3. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article
    4. Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing. Jaramillo-Lambert A, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740937, Free PMC Article
    5. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion.
      Title: SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Neuroblastoma-amplified sequence
    NP_001369949.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7918447..7926338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383416.2 → NP_001369949.1  Neuroblastoma-amplified sequence [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90841
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools