U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    kcnl-1 Calmodulin-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180280, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    kcnl-1
    Official Full Name
    Calmodulin-binding domain-containing protein
    Primary source
    WormBase:WBGene00007176
    Locus tag
    CELE_B0399.1
    See related
    AllianceGenome:WB:WBGene00007176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in body wall musculature; neurons; and non-striated muscle. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See kcnl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (19565382..19606124)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene Glycine Rich Secreted Protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A single-nucleotide change underlies the genetic assimilation of a plastic trait. Vigne P, et al. Sci Adv, 2021 Feb. PMID 33536214, Free PMC Article
    2. Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off. Mignerot L, et al. Elife, 2024 Apr 2. PMID 38564369, Free PMC Article
    3. Determining genetic expression profiles in C. elegans using microarray and real-time PCR. Guthmueller KL, et al. J Vis Exp, 2011 Jul 30. PMID 21841763, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Calmodulin-binding domain-containing protein
    NP_001041074.1
    • Confirmed by transcript evidence
    NP_001041075.1
    • Confirmed by transcript evidence
    NP_001122838.1
    • Confirmed by transcript evidence
    NP_001379314.1
    • Confirmed by transcript evidence
    NP_507800.2
    • Partially confirmed by transcript evidence
    NP_872183.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19565382..19606124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392703.1 → NP_001379314.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDG3
      Conserved Domains (3) summary
      smart01053
      Location:514 → 589
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:219 → 330
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:447 → 500
      Ion_trans_2; Ion channel

    2. NM_075399.5 → NP_507800.2  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507800.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFI1
      Conserved Domains (4) summary
      smart01053
      Location:561 → 636
      CaMBD; Calmodulin binding domain
      PHA03253
      Location:29 → 163
      PHA03253; UL35; Provisional
      pfam03530
      Location:266 → 377
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:494 → 547
      Ion_trans_2; Ion channel

    3. NM_001129366.4 → NP_001122838.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED53
      Conserved Domains (3) summary
      smart01053
      Location:464 → 539
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:169 → 280
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:397 → 450
      Ion_trans_2; Ion channel

    4. NM_001047609.4 → NP_001041074.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EER9
      Conserved Domains (3) summary
      smart01053
      Location:449 → 524
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:154 → 265
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:382 → 435
      Ion_trans_2; Ion channel

    5. NM_001047610.5 → NP_001041075.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEZ9
      Conserved Domains (3) summary
      smart01053
      Location:380 → 455
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:85 → 196
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:313 → 366
      Ion_trans_2; Ion channel

    6. NM_182383.5 → NP_872183.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4D2
      Conserved Domains (3) summary
      smart01053
      Location:324 → 399
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:29 → 140
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:257 → 310
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous