rig-3 Neuronal immunoglobulin domain-containing protein rig-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rig-3
Official Full Name: Neuronal immunoglobulin domain-containing protein rig-3
Primary source: WormBase:WBGene00004370
Locus tag: CELE_C53B7.1
See related: AllianceGenome:WB:WBGene00004370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in axon and synapse. Is expressed in several structures, including AVA; amphid sheath cell; coelomocyte; dorsal nerve cord; and pharyngeal neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rig-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (6853618..6860922)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results further suggest that animals lacking rig-3 show increased AVA activity, allowing the release of FLP-18 neuropeptide from AVA, which is an activity-dependent signaling molecule.
Title: Control of Locomotory Behavior of Caenorhabditis elegans by the Immunoglobulin Superfamily Protein RIG-3.
RIG-3 inhibits Wnt/LIN-44 signaling pathway through interaction with CAM-1.
Title: Regulation of WNT Signaling at the Neuromuscular Junction by the Immunoglobulin Superfamily Protein RIG-3 in Caenorhabditis elegans.
results identify RIG-3 as a regulator of Wnt signaling, and suggest that RIG-3 has an anti-plasticity function preventing activity-induced changes in postsynaptic receptor fields.
Title: The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C53B7.1 (e-PCR)
- UniSTS:309403

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neuronal immunoglobulin domain-containing protein rig-3

NP_509155.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6853618..6860922

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076754.5 → NP_509155.1 Neuronal immunoglobulin domain-containing protein rig-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509155.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18806

Conserved Domains (2) summary

smart00410
Location:48 → 142

IG_like; Immunoglobulin like

cd00096
Location:267 → 341

Ig; Immunoglobulin domain