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    sam-10 Single-stranded DNA-binding protein homolog sam-10 [ Caenorhabditis elegans ]

    Gene ID: 174975, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sam-10
    Official Full Name
    Single-stranded DNA-binding protein homolog sam-10
    Primary source
    WormBase:WBGene00012990
    Locus tag
    CELE_Y48C3A.8
    See related
    AllianceGenome:WB:WBGene00012990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of gene expression; nervous system development; and regulation of protein localization to synapse. Located in nucleus. Is expressed in ganglia; touch receptor neurons; and vulva. Orthologous to several human genes including SSBP3 (single stranded DNA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sam-10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (13321024..13330525, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine-rich adhesin for platelets;Uncharacterized protein;uncharacterized protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Failed axon connections homolog Neighboring gene Protein mac-1 Neighboring gene ncRNA Neighboring gene Mitochondrial Ribosomal Protein, Large

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10. Zheng Q, et al. Development, 2011 Jan. PMID 21115607, Free PMC Article
    2. Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development. Suzuki Y, et al. Genes Dev, 2006 Feb 15. PMID 16481471, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Single-stranded DNA-binding protein homolog sam-10
    NP_001254379.1
    • Confirmed by transcript evidence
    NP_001254380.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13321024..13330525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267450.2 → NP_001254379.1  Single-stranded DNA-binding protein homolog sam-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254379.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FAS6, B7FAS7
      Conserved Domains (1) summary
      smart00667
      Location:20 → 46
      LisH; Lissencephaly type-1-like homology motif

    2. NM_001267451.3 → NP_001254380.1  Single-stranded DNA-binding protein homolog sam-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FAS6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7FAS6.1

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