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    ntl-2 NOT2/NOT3/NOT5 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ntl-2
    Official Full Name
    NOT2/NOT3/NOT5 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00003825
    Locus tag
    CELE_B0286.4
    See related
    AllianceGenome:WB:WBGene00003825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in regulation of DNA-templated transcription and regulation of stem cell population maintenance. Predicted to be located in cytoplasm. Predicted to be part of CCR4-NOT core complex. Is expressed in several structures, including hypodermis; intestine; nervous system; rectal gland cell; and reproductive system. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ntl-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (4372739..4376458, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Peptidase S1 domain-containing protein Neighboring gene Phosphoribosylaminoimidazole-succinocarboxamide synthase Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Forkhead transcription factor fkh-6 Neighboring gene Peroxidase mlt-7 light chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Kuzuoglu-Öztürk D, et al. Nucleic Acids Res, 2012 Jul. PMID 22402495, Free PMC Article
    2. The Caenorhabditis elegans Argonautes ALG-1 and ALG-2: almost identical yet different. Tops BB, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381296
    3. The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. Nousch M, et al. J Cell Sci, 2013 Sep 15. PMID 23843623
    4. The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Rocheleau CE, et al. Genetics, 2008 Mar. PMID 18245826, Free PMC Article
    5. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NOT2/NOT3/NOT5 C-terminal domain-containing protein
    NP_001040726.1
    • Confirmed by transcript evidence
    NP_001379564.1
    • Confirmed by transcript evidence
    NP_494772.1
    • Confirmed by transcript evidence
    NP_494773.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4372739..4376458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393050.1 → NP_001379564.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QZ3
      Conserved Domains (1) summary
      pfam04153
      Location:101 → 221
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    2. NM_062372.6 → NP_494773.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QZ4
      Conserved Domains (1) summary
      pfam04153
      Location:150 → 271
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    3. NM_062371.6 → NP_494772.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q10923
      Conserved Domains (1) summary
      pfam04153
      Location:227 → 348
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    4. NM_001047261.5 → NP_001040726.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2MZA9
      Conserved Domains (1) summary
      pfam04153
      Location:141 → 262
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    Nucleotide Protein
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